ethyl 2-((2-(2-fluorophenyl)-5-methylimidazo[1,2-a]pyridin-3-yl)amino)acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 2-((2-(2-fluorophenyl)-5-methylimidazo[1,2-a]pyridin-3-yl)amino)acetate
• 英文别名: Ethyl 2-[[2-(2-fluorophenyl)-5-methylimidazo[1,2-a]pyridin-3-yl]amino]acetate
• 化学式: C₁₈H₁₈FN₃O₂
• 分子量: 327.358
• InChiKey: LHLRQSLFTNEKEU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-6-甲基吡啶 、 异氰基乙酸乙酯 、 2-氟苯甲醛 在 sulfonated β-cyclodextrin 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以89%的产率得到ethyl 2-((2-(2-fluorophenyl)-5-methylimidazo[1,2-a]pyridin-3-yl)amino)acetate
  参考文献：
  名称：

  A Facile Preparation of Imidazo[1,2-a]pyridin-3-amine Derivatives via a Three-Component Reaction with β-Cyclodextrin–SO3H as Catalyst

  摘要：

  Because heterogeneous catalysts have attracted great interest in organic chemistry, this paper reports facile beta-cyclodextrin-SO3H catalyzed cyclization to form imidazo[1,2-a]pyridin-3-amine derivatives via a three-component reaction. The main advantages of this strategy include short reaction time, practical simplicity, and high yield, and the catalyst can be separated easily by filtration and reused at least four times.

  DOI：

  10.3987/com-16-13508

文献信息

• A Facile Preparation of Imidazo[1,2-a]pyridin-3-amine Derivatives via a Three-Component Reaction with β-Cyclodextrin–SO3H as Catalyst
  作者：Jian Wu、Fang-Zhou Xu、She-Lei Feng、Wei Xue、Zhen-Zhen Wang

  DOI：10.3987/com-16-13508

  日期：——

  Because heterogeneous catalysts have attracted great interest in organic chemistry, this paper reports facile beta-cyclodextrin-SO3H catalyzed cyclization to form imidazo[1,2-a]pyridin-3-amine derivatives via a three-component reaction. The main advantages of this strategy include short reaction time, practical simplicity, and high yield, and the catalyst can be separated easily by filtration and reused at least four times.