2-acetoxyethyl trimethyl acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-acetoxyethyl trimethyl acetate
• 英文别名: 2-Acetyloxyethyl 2,2-dimethylpropanoate
• 化学式: C₉H₁₆O₄
• 分子量: 188.224
• InChiKey: XOAJXCGXEYRCLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  三甲基氯硅烷 、 2-acetoxyethyl trimethyl acetate 在 sodium 作用下， 以 甲苯 为溶剂， 以41%的产率得到(E)-4,4-Dimethyl-2,3-bis-trimethylsilanyloxy-pent-2-ene
  参考文献：
  名称：

  Die Acyloin-Kondensation von 1,2-Diacyloxyethanen; Gezielte Darstellung unsymmetrisch substituierter 1,2-Bis-(trimethylsiloxy)ethene

  摘要：

  A synthesis specifically directed to unsymmetrically substituted 1,2-bis-(trimethylsiloxy)ethenes (2a-d), precursors of the corresponding acyloins, was accomplished by intramolecular acyloin condensation of the unsymmetrical 1,2-diacyloxyethanes (1a-d) with sodium in toluene/chlorotrimethylsilane.

  DOI：

  10.1002/prac.19953370114
• 作为产物：
  描述：

  2-亚甲基-1,3-二氧戊环 、 三甲基乙酸 以 四氢呋喃 为溶剂， 反应 4.0h， 以94%的产率得到2-acetoxyethyl trimethyl acetate
  参考文献：
  名称：

  通过环丁烯缩醛中间体对二元醇进行选择性二酯化。

  摘要：

  DOI：

  10.1021/jo990227g

文献信息

• [EN] CALCIUM RECEPTOR MODULATING ARYLALKYLAMINES<br/>[FR] ARYLALKYLAMINES MODULANT UN RECEPTEUR CALCIQUE
  申请人：AMGEN INC

  公开号：WO2003099776A1

  公开（公告）日：2003-12-04

  The compounds of the invention are represented by the following general structure (I) or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or inhibit PTH secretion, including methods for reducing or inhibiting PTH secretion and methods for treatment or prophylaxis of diseases associated with bone disorders, such as osteoporosis, or associated with excessive secretion of PTH, such as hyperparathyroidism. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  该发明的化合物由以下一般结构（I）或其药用可接受盐所代表，以及含有它们的组合物，其中变量在此处定义，并且它们的用途是减少或抑制PTH分泌，包括减少或抑制PTH分泌的方法以及用于治疗或预防与骨骼疾病相关的疾病的方法，例如骨质疏松症，或与PTH过度分泌相关的疾病，例如甲状旁腺功能亢进症。该主题发明还涉及制备此类化合物的过程，以及在此类过程中有用的中间体。
• [EN] PYRIMIDINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS AND THEIR USE IN THE TREATMENT OF PAIN<br/>[FR] DERIVES DE PYRIMIDINE UTILISES COMME LIGANDS DE RECEPTEUR DE VANILLOIDE ET LEUR UTILISATION DANS LE TRAITEMENT DE LA DOULEUR
  申请人：AMGEN INC

  公开号：WO2005077944A1

  公开（公告）日：2005-08-25

  Pyrimidine ethers and compositions containing them, fo use as vanilloid receptor ligands for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders. Wherein R1 - R4 and X are as defined in the claims.

  含有嘧啶醚化合物的组合物，用作vanilloid受体配体，用于治疗急性、炎症性和神经病理性疼痛、牙痛、普通头痛、偏头痛、群集性头痛、混合血管和非血管综合症、紧张性头痛、一般炎症、关节炎、风湿病、骨关节炎、炎症性肠病、炎症性眼病、炎症性或不稳定膀胱疾病、牛皮癣、具有炎症成分的皮肤疾病、慢性炎症状态、炎症性疼痛及相关的高敏性和触痛、神经病理性疼痛及相关的高敏性和触痛、糖尿病性神经病疼痛、交感神经维持的疼痛、去神经症候群、哮喘、上皮组织损伤或功能障碍、单纯疱疹、呼吸、泌尿、胃肠或血管区域内脏运动障碍、创伤、烧伤、过敏性皮肤反应、瘙痒、白癜风、一般胃肠道疾病、胃溃疡、十二指肠溃疡、腹泻、坏死性剂引起的胃病变、毛发生长、血管运动性或过敏性鼻炎、支气管疾病或膀胱疾病。其中R1-R4和X的定义如权利要求中所述。
• Environmentally preferred fluids and fluid blends
  申请人：——

  公开号：US20020002933A1

  公开（公告）日：2002-01-10

  The invention concerns fluids that have a low reactivity with respect to ozone formation, blends thereof, and the replacement of conventional industrial solvents with said fluid or fluid blends in order to reduce troposheric ozone formation.

  本发明涉及对臭氧形成反应性较低的流体，其混合物以及用该流体或流体混合物替代传统工业溶剂以减少对对流层臭氧形成的影响。
• Indole-2-carboxylic acid derivatives
  申请人：GLAXO S.p.A.

  公开号：EP0568136A1

  公开（公告）日：1993-11-03

  The invention relates to compounds of formula (I). or a salt, or metabolically labile ester thereof wherein R represents a group selected from halogen, alkyl, alkoxy, amino, alkylamino, dialkylamino, hydroxy, trifluoromethyl, trifluoromethoxy, nitro, cyano, SO₂R₁ or COR₁ wherein R₁ represents hydroxy, methoxy, or amino; m is zero or an integer 1 or 2; A represents an ethynyl group or an optionally substituted ethenyl, or cyclopropyl group; X represents -O- or NH; R₂ represents an aryl group and when X represents an oxygen atom R₂ may also represent a hydrogen atom or an alkyl group; which are antagonists of excitatory amino acids, to processes for their preparation and to their use in medicine.

  本发明涉及式 (I) 化合物。 其中 R 代表选自卤素、烷基、烷氧基、氨基、烷基氨基、二烷基氨基、羟基、三氟甲基、三氟甲氧基、硝基、氰基、SO₂R₁ 或 COR₁ 的基团，其中 R₁ 代表羟基、甲氧基或氨基；m 为零或 1 或 2 的整数； A 代表乙炔基或任选取代的乙烯基或环丙基； X 代表-O-或 NH； R₂代表芳基，当 X 代表氧原子时，R₂也可以代表氢原子或烷基。
• ENVIRONMENTALLY PREFERRED FLUIDS AND FLUID BLENDS
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP1090085A1

  公开（公告）日：2001-04-11