9-(4-methylphenethyl)-9H-carbazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-(4-methylphenethyl)-9H-carbazole
• 英文别名: 9-[2-(4-Methylphenyl)ethyl]carbazole；9-[2-(4-methylphenyl)ethyl]carbazole
• 化学式: C₂₁H₁₉N
• 分子量: 285.389
• InChiKey: RIHBEDNZFQPTHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  4.9
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  N-乙烯基咔唑 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 caesium carbonate 作用下， 以 水 、 甲苯 为溶剂， 反应 12.0h， 生成 9-(4-methylphenethyl)-9H-carbazole
  参考文献：
  名称：

  β-Aminoethyltrifluoroborates:  Efficient Aminoethylations via Suzuki−Miyaura Cross-Coupling

  摘要：

  A set of phenethylamines has been successfully prepared via Suzuki-Miyaura cross-coupling of diverse potassium beta-aminoethyltrifluoroborates with aryl halides. The potassium beta-aminoethyltrifluoroborates were easily prepared via hydroboration of enamine and enamide precursors.

  DOI：

  10.1021/ol062610v

文献信息

• PKC Delta Inhibitors for use as Therapeutics
  申请人：FALLER Douglas V.

  公开号：US20150283114A1

  公开（公告）日：2015-10-08

  The invention directed to compounds that are specific inhibitors of PKC delta, and methods and compositions for the treatment and prevent of cancers and other disorders. Compositions comprising compounds of the invention are used to treat cancers such as, for example, carcinoid and neuroendocrine tumors, malignant melanomas, pancreatic, gastrointestinal and lung cancers. Neuroendocrine tumor cell lines of pulmonary and gastrointestinal origin are surprisingly sensitive to PKC delta inhibition by the compounds of the invention. The invention is further directed to methods, compositions and kits containing compounds of the formulas (Ia), (Ib), (IIa), (IIb), (IIIa), (IIIb), (IVa), (IVb), and (V) as disclosed and described in FIGS. 11 and 12.

  本发明涉及到特异性抑制PKC delta的化合物，以及用于治疗和预防癌症和其他疾病的方法和组合物。包含本发明化合物的组合物可用于治疗癌症，如类癌和神经内分泌肿瘤、恶性黑色素瘤、胰腺、胃肠和肺癌等。神经内分泌肿瘤细胞系源于肺和胃肠道对本发明化合物的PKC delta抑制作用具有惊人的敏感性。本发明还涉及到包含公式(Ia)、(Ib)、(IIa)、(IIb)、(IIIa)、(IIIb)、(IVa)、(IVb)和(V)的化合物的方法、组合物和试剂盒，如图11和12所述。
• US9364460B2
  申请人：——

  公开号：US9364460B2

  公开（公告）日：2016-06-14
• US9572793B2
  申请人：——

  公开号：US9572793B2

  公开（公告）日：2017-02-21
• β-Aminoethyltrifluoroborates:  Efficient Aminoethylations via Suzuki−Miyaura Cross-Coupling
  作者：Gary A. Molander、Fabricio Vargas

  DOI：10.1021/ol062610v

  日期：2007.1.1

  A set of phenethylamines has been successfully prepared via Suzuki-Miyaura cross-coupling of diverse potassium beta-aminoethyltrifluoroborates with aryl halides. The potassium beta-aminoethyltrifluoroborates were easily prepared via hydroboration of enamine and enamide precursors.