N-diphenylmethyl-isobutylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-diphenylmethyl-isobutylamine
• 英文别名: N-benzhydryl-2-methylpropan-1-amine
• 化学式: C₁₇H₂₁N
• mdl: MFCD11139775
• 分子量: 239.36
• InChiKey: LECFMKRWPRAFAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.294
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-diphenylmethyl-isobutylamine 在 4 A molecular sieve 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 苯 为溶剂， 反应 1.0h， 生成 N-(iso-Butyl)-diphenylmethanimin
  参考文献：
  名称：

  Oxidative Deprotection of Diphenylmethylamines

  摘要：

  [GRAPHICS]The diphenylmethyl amino protecting group can be efficiently removed by initial oxidation of the amine to an imine by 2,3-dichloro-5,6-dicyanobenzoquinone. The resulting imine can then be easily hydrolyzed under mildly acidic conditions. This method is particularly well suited for the preparation of alpha-amino phosphinates and alpha-amino phosphonates.

  DOI：

  10.1021/ol990956i
• 作为产物：
  描述：

  异丁醛 、 二苯甲胺 在 sodium cyanoborohydride 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 25.0h， 以58%的产率得到N-diphenylmethyl-isobutylamine
  参考文献：
  名称：

  Oxidative Deprotection of Diphenylmethylamines

  摘要：

  [GRAPHICS]The diphenylmethyl amino protecting group can be efficiently removed by initial oxidation of the amine to an imine by 2,3-dichloro-5,6-dicyanobenzoquinone. The resulting imine can then be easily hydrolyzed under mildly acidic conditions. This method is particularly well suited for the preparation of alpha-amino phosphinates and alpha-amino phosphonates.

  DOI：

  10.1021/ol990956i

文献信息

• Enantioselective palladium-catalyzed C(sp2)-H carbamoylation
  作者：Wenfeng Dong、Guangqing Xu、Wenjun Tang

  DOI：10.1016/j.tet.2019.03.038

  日期：2019.6

  An enantioselective palladium-catalyzed C(sp(2))-H carbamoylation for the preparation of chiral iso-indolines was described for the first time. With chiral monophosphorus ligand (R)-AntPhos as the ligand, a series of chiral isoindolines were prepared from diarylmethyl carbamoyl chlorides in excellent yields and enantioselectivities with the palladium loading as low as 1 mol%. Initial mechanistic studies indicated the asymmetric cyclization catalyzed a palladium species with a single chiral monophosphorus ligand. (C) 2019 Elsevier Ltd. All rights reserved.
• HU LEANG; MAUZE B.; MIGINIAC L., C. R. ACAD. SCI., 1977, C 284, NO 4, 195-198
  作者：HU LEANG、 MAUZE B.、 MIGINIAC L.

  DOI：——

  日期：——
• Oxidative Deprotection of Diphenylmethylamines
  作者：Peter B. Sampson、John F. Honek

  DOI：10.1021/ol990956i

  日期：1999.11.1

  [GRAPHICS]The diphenylmethyl amino protecting group can be efficiently removed by initial oxidation of the amine to an imine by 2,3-dichloro-5,6-dicyanobenzoquinone. The resulting imine can then be easily hydrolyzed under mildly acidic conditions. This method is particularly well suited for the preparation of alpha-amino phosphinates and alpha-amino phosphonates.