2′-methoxy-2,4-dimethyl-1,1′-biphenyl

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2′-methoxy-2,4-dimethyl-1,1′-biphenyl
• 英文别名: 1-(2-Methoxyphenyl)-2,4-dimethylbenzene；1-(2-methoxyphenyl)-2,4-dimethylbenzene
• 化学式: C₁₅H₁₆O
• 分子量: 212.291
• InChiKey: DPEVEVXEJMEEIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-溴苯甲醚 在 Pd-PEPPSI-IPent 、 叔丁基锂 作用下， 以 四氢呋喃 、 甲苯 、 正戊烷 为溶剂， 生成 2′-methoxy-2,4-dimethyl-1,1′-biphenyl
  参考文献：
  名称：

  有机锂化合物与芳基氯化物的催化直接交叉偶联

  摘要：

  据报道，钯催化的芳基氯化物与多种（杂）芳基锂化合物的直接交叉偶联。通过使用Pd-PEPPSI-IPent或Pd 2（dba）3 / XPhos作为催化剂，可以在温和的条件下（室温至40°C）以较短的反应时间高产率地制备联芳基和杂联芳基化合物。

  DOI：

  10.1021/ol402408v

文献信息

• [EN] 3,7-DIAZABICYCLO[3.3.1]NONANE AND 9-OXA-3,7-DIAZABICYCLO[3.3.1]NONANE DERIVATIVES<br/>[FR] DÉRIVÉS DE 3,7-DIAZABICYCLO[3.3.1]NONANE ET DE 9-OXA-3,7- DIAZABICYCLO[3.3.1]NONANE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2013050938A1

  公开（公告）日：2013-04-11

  The present invention relates to 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7- diazabicyclo[3.3.1 ]nonane derivatives of formula (I) wherein Ar1 and Ar2 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

  本发明涉及式（I）的3,7-二氮杂双环[3.3.1]壬烷和9-氧-3,7-二氮杂双环[3.3.1]壬烷衍生物，其中Ar1和Ar2如描述中所述，其制备方法，其药学上可接受的盐，以及作为药物的用途，含有一种或多种式（I）化合物的药物组合物，特别是其用作促进睡眠受体拮抗剂。
• Pd-PEPPSI Complexes Bearing Bulky [(1,2-Di-(<i>tert</i>-butyl)acenaphthyl] (DtBu-An) on <i>N</i>-Heterocarbene Backbones: Highly Efficient for Suzuki–Miyaura Cross-Coupling under Aerobic Conditions
  作者：Xiao-Bing Lan、Fu-Min Chen、Bei-Bei Ma、Dong-Sheng Shen、Feng-Shou Liu

  DOI：10.1021/acs.organomet.6b00723

  日期：2016.11.28

  With the goal of achieving highly efficient palladium catalyzed cross-coupling reactions under mild reaction conditions, the Pd-PEPPSI complexes Cl and C2 bearing 1,2-di(tert-butyl)acenaphthyl (DtBu-An) backbones were synthesized and characterized, and their use in Suzuki Miyaura cross-coupling was investigated. The effects of catalyst structure and reaction conditions on the cross-coupling efficiency were evaluated in detail. The significant differences in catalytic activity compared with classical PEPPSI-IPr and PEPPSI-IPrAn precatalysts are discussed, where the axial sterics on the backbone play an important role. At low palladium loadings of 0.05-0.1 mol % and upon the addition of the relatively weak base K3PO4, the palladium complex Cl was found to be highly efficient for the coupling of (hetero)aryl chlorides with arylboronic acids under aerobic conditions, affording the corresponding biaryls in excellent yields.