(S)-methyl-2-((2,5-dimethylphenyl)amino)propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-methyl-2-((2,5-dimethylphenyl)amino)propanoate
• 英文别名: Methyl (2,5-dimethylphenyl)-L-alaninate；methyl (2S)-2-(2,5-dimethylanilino)propanoate
• 化学式: C₁₂H₁₇NO₂
• 分子量: 207.272
• InChiKey: LKRHNMWYCVMUPH-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-酞酰亚胺基丙酸甲酯 、 对二甲苯 在 Co(dmgH)(dmgH₂)Cl₂ 、 10-甲基-9-均三甲苯基吖啶高氯酸盐 作用下， 以 乙腈 为溶剂， 反应 72.0h， 以53%的产率得到(S)-methyl-2-((2,5-dimethylphenyl)amino)propanoate
  参考文献：
  名称：

  Photocatalytic Hydrogen-Evolving Cross-Coupling of Arenes with Primary Amines

  摘要：

  Herein, we described a cooperative catalyst system consisting of an acridinium photoredox catalyst and a cobalt-based proton-reduction catalyst that is effective for the C-H amination of arenes with concomitant generation of hydrogen. This oxidant free method allows a variety of amines with diverse functional groups to be converted to aromatic amines. Additionally, this protocol can also be extended to hydrolytically unstable benzophenone imines.

  DOI：

  10.1021/acs.orglett.8b03089

文献信息

• Photocatalytic Hydrogen-Evolving Cross-Coupling of Arenes with Primary Amines
  作者：Fengqian Zhao、Qiong Yang、Jingjie Zhang、Weimin Shi、Huanhuan Hu、Fang Liang、Wei Wei、Shaolin Zhou

  DOI：10.1021/acs.orglett.8b03089

  日期：2018.12.21

  Herein, we described a cooperative catalyst system consisting of an acridinium photoredox catalyst and a cobalt-based proton-reduction catalyst that is effective for the C-H amination of arenes with concomitant generation of hydrogen. This oxidant free method allows a variety of amines with diverse functional groups to be converted to aromatic amines. Additionally, this protocol can also be extended to hydrolytically unstable benzophenone imines.