(4S,5S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-(2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl)dihydrofuran-2(3H)-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (4S,5S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-(2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl)dihydrofuran-2(3H)-one
• 英文别名: (4S,5S)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-[2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl]oxolan-2-one
• 化学式: C₂₃H₃₆O₅S₂Si
• 分子量: 484.753
• InChiKey: RLHUTOGLAZWVIM-FXAWDEMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.68
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (4S,5S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-(2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl)dihydrofuran-2(3H)-one 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以95%的产率得到(4S,5S)-4-(2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl)-5-(hydroxymethyl)dihydrofuran-2(3H)-one
  参考文献：
  名称：

  Design, synthesis, and evaluation of DNA topoisomerase II-targeted nucleosides

  摘要：

  We developed novel nucleoside-based topoisomerase II selective inhibitors and showed that small structural units, such as catechols, are essential for DNA topoisomerase II inhibitory activity. Moreover, nucleoside analogues containing TBS and 1,3-dithian moieties had potent and selective DNA topoisomerase II inhibitory activities. In further experiments, compound 25b having a beta configuration of the thymine moiety showed relatively strong growth inhibitory activity against cancer cell lines, and was more potent against all cancer cell lines than compound 26b, which carries a thymine moiety in the alpha configuration. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2017.06.001
• 作为产物：
  描述：

  (5S)-5-(tert-butyldimethylsilanyloxymethyl)-5H-furan-2-one 、 2-(3,4-二甲氧基-苯基)-[1,3]二噻烷 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以80%的产率得到(4S,5S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-(2-(3,4-dimethoxyphenyl)-1,3-dithian-2-yl)dihydrofuran-2(3H)-one
  参考文献：
  名称：

  Design, synthesis, and evaluation of DNA topoisomerase II-targeted nucleosides

  摘要：

  We developed novel nucleoside-based topoisomerase II selective inhibitors and showed that small structural units, such as catechols, are essential for DNA topoisomerase II inhibitory activity. Moreover, nucleoside analogues containing TBS and 1,3-dithian moieties had potent and selective DNA topoisomerase II inhibitory activities. In further experiments, compound 25b having a beta configuration of the thymine moiety showed relatively strong growth inhibitory activity against cancer cell lines, and was more potent against all cancer cell lines than compound 26b, which carries a thymine moiety in the alpha configuration. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2017.06.001