methyl 3-(2'-methoxyphenyl)-2-methylpropanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3-(2'-methoxyphenyl)-2-methylpropanoate
• 英文别名: Methyl 3-(2-methoxyphenyl)-2-methylpropanoate
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: VVDUVBHTZSLDAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-[Acetoxy-(2-methoxy-phenyl)-methyl]-acrylic acid methyl ester 在 三氢化钐 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以79%的产率得到methyl 3-(2'-methoxyphenyl)-2-methylpropanoate
  参考文献：
  名称：

  Sm/HOAc/EtOH System–Mediated Reduction of Baylis–Hillman Acetates

  摘要：

  Selective formation of (2E)-2-methylalk-2-enoates or 2-methyl alkanoates could be achieved in moderate to good yields under mild conditions via Sm/HOAc/EtOH system-mediated reduction of Baylis-Hillman acetates depending on the amount of samariurn consumed in the reactions.

  DOI：

  10.1080/00397910701577570

文献信息

• Parameters Influencing Reactivity and Regioselectivity in the Methoxycarbonylation of Arylalkenes
  作者：Barend Bezuidenhoudt、Maretha du Plessis、Charlene Marais

  DOI：10.1055/s-0035-1560912

  日期：——

  hydroformylation and hydroesterification reactions. However, little is known in this regard about the influence of the steric and electronic environment around the double bond of the substrate. A variety of arylalkenes were therefore subjected to methoxycarbonylation to investigate the steric and electronic effects of substituents on the aromatic ring of the substrate on the regioselectivity and reactivity in the

  摘要 先前的研究表明，配体的空间体积，电子性质和咬合角对加氢甲酰化和加氢酯化反应的催化剂活性和区域选择性都有影响。然而，在这方面，关于衬底的双键周围的空间和电子环境的影响知之甚少。因此，对各种芳基烯烃进行甲氧基羰基化反应，以研究底物芳环上取代基的空间和电子效应，这些底物与Pd（II）/ Al（OTf）3 /的甲氧基羰基化反应的区域选择性和反应性。Ph 3 P催化剂体系。 先前的研究表明，配体的空间体积，电子性质和咬合角对加氢甲酰化和加氢酯化反应的催化剂活性和区域选择性都有影响。然而，在这方面，关于衬底的双键周围的空间和电子环境的影响知之甚少。因此，对各种芳基烯烃进行甲氧基羰基化反应，以研究底物芳环上取代基的空间和电子效应，这些底物与Pd（II）/ Al（OTf）3 /的甲氧基羰基化反应的区域选择性和反应性。Ph 3 P催化剂体系。
• [EN] COMPOUNDS AND METHODS<br/>[FR] COMPOSÉS ET MÉTHODES
  申请人：TEMPERO PHARMACEUTICALS INC

  公开号：WO2013019635A1

  公开（公告）日：2013-02-07

  The present invention relates to novel retinoid-reiated orphan receptor gamma (RORy) modulators and their use in the treatment of diseases mediated by RORy.

  本发明涉及新型视黄醇相关孤儿受体γ（RORγ）调节剂及其在治疗由RORγ介导的疾病中的应用。
• Catalyst components for the polymerization of olefins
  申请人：Basell Poliolefine Italia S.r.l.

  公开号：EP2583985A1

  公开（公告）日：2013-04-24

  Catalyst component for the polymerization of olefins comprising Mg, Ti and an electron donor compound of the following formula (I) In which R to R4 groups, equal to or different from each other, are hydrogen, halogen or C1-C15 hydrocarbon groups, optionally containing an heteroatom selected from halogen, P, S, N and Si, which may be linked to form a saturated or unsaturated mono or polycycle and R5 groups, are selected from C1-C15 hydrocarbon groups optionally containing an heteroatom selected from halogen, P, S, N and Si.

  用于烯烃聚合的催化剂组分，由 Mg、Ti 和下式 (I) 的电子供体化合物组成 其中 R 至 R4 基团（彼此相等或不同）为氢、卤素或 C1-C15 烃基，可选择含有选自卤素、P、S、N 和 Si 的杂原子，它们可连接形成饱和或不饱和单环或多环及 R5 基团，可选择含有选自卤素、P、S、N 和 Si 的杂原子的 C1-C15 烃基。
• Palladium catalyzed hydroesterification of substituted alkenes under microwave conditions
  作者：Maretha du Plessis、Charlene Marais、Barend C. B. Bezuidenhoudt

  DOI：10.24820/ark.5550190.p011.198

  日期：——

  While several catalyst systems have been utilized in the hydroesterification or methoxycarbonylation of alkenes or equivalent substrates, these reactions are conventionally performed in autoclave reactor systems under high CO pressure (20 - 70 bar) and thermal heating (70 - 110 degrees C). In this paper, the first methoxycarbonylation reactions performed in a microwave reactor fitted with a gas-addition accessory system are reported on and compared to the same reactions performed under conventional heating in an autoclave reactor. Thus 1-octene, styrene, allylbenzene, o- and p-methoxyallylbenzene and beta-methylstyrene were subjected to methoxycarbonylation over a palladium acetate-aluminum triflate catalyst system at 12 bar and 95 degrees C. Results obtained indicated the methoxycarbonylation of these alkenes to be much faster under microwave conditions when compared to conventional heating and improvements in conversion ranged between 3 and 5% for the more reactive substrates (1-octene and styrene) and 6 - 20% for the allylbenzenes and beta-methylstyrene.[GRAPHICS].
• COMPOUNDS AND METHODS
  申请人：Tempero Pharmaceuticals, Inc.

  公开号：EP2747560A1

  公开（公告）日：2014-07-02