1,5-dimethyl-4-[(E)-[(6-methyl-[1,3]dioxolo[4,5-g]quinolin-8-yl)hydrazinylidene]methyl]-2-phenylpyrazol-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1,5-dimethyl-4-[(E)-[(6-methyl-[1,3]dioxolo[4,5-g]quinolin-8-yl)hydrazinylidene]methyl]-2-phenylpyrazol-3-one
• 化学式: C₂₃H₂₁N₅O₃
• 分子量: 415.4
• InChiKey: KDOGTBIAIRUFRD-WYMPLXKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  79.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• COMPOUNDS AND METHODS FOR INHIBITION OF AP ENDONUCLEASE-1/REDOX FACTOR-1 (HAPE1) ACTIVITY
  申请人：University of Pittsburgh - Of the Commonwealth System of High Education

  公开号：US20140371259A1

  公开（公告）日：2014-12-18

  A method for treating a neoplasm in a subject, comprising co-administering to the subject a therapeutically effective amount of an anticancer agent and a substituted 6,7-methylenedioxy-4-amino-quinoline, or a pharmaceutically acceptable salt or ester thereof.
• US9624235B2
  申请人：——

  公开号：US9624235B2

  公开（公告）日：2017-04-18
• [EN] COMPOUNDS AND METHODS FOR INHIBITION OF AP ENDONUCLEASE-1/ REDOX FACTOR-1 (HAPE1) ACTIVITY<br/>[FR] COMPOSÉS ET MÉTHODES D'INHIBITION DE L'ACTIVITÉ DE L'AP ENDONUCLÉASE-1/FACTEUR REDOX-1 (HAPE1)
  申请人：UNIV PITTSBURGH

  公开号：WO2013116228A1

  公开（公告）日：2013-08-08

  A method for treating a neoplasm in a subject, comprising co-administering to the subject a therapeutically effective amount of an anticancer agent and a substituted 6,7-methylenedioxy-4-amino-quinoline, or a pharmaceutically acceptable salt or ester thereof.