双[4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基)苯基]苯膦 | 892154-91-5

• 物质功能分类: 化学试剂 - 有机试剂 - 膦配体
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 双[4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基)苯基]苯膦
• 中文别名: 双[4-（1H，1H，2H，2H-全氟癸基）苯基]苯基膦
• 英文名称: bis[4-(1H,1H,2H,2H-perfluoro-7-decyl)phenyl]phenylphospine
• 英文别名: Bis[4-(1H,1H,2H,2H-perfluorodecyl)phenyl]phenylphosphine；bis[4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl]-phenylphosphane
• CAS: 892154-91-5
• 化学式: C₃₈H₂₁F₃₄P
• 分子量: 1154.5
• InChiKey: GMHNZJNJORCMQJ-UHFFFAOYSA-N

物化性质

• 熔点：
  65-71 °C

计算性质

• 辛醇/水分配系数(LogP)：
  17.5
• 重原子数：
  73
• 可旋转键数：
  21
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  34

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  双[4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基)苯基]苯膦 、 [RuCl2(η6-C6H5(CH2)2CH(OH)CH3)]2 以 氯仿 为溶剂， 以88%的产率得到[Ru(η6-4-phenyl-2-butanol)Cl2(PPh(p-C6H4C2H4C8H17)2)]
  参考文献：
  名称：

  Use of Perfluorinated Phosphines to Provide Thermomorphic Anticancer Complexes for Heat-Based Tumor Targeting

  摘要：

  A series of compounds of general formula [Ru(eta(6)-arene)(pta)(PR3)Cl]BF4 (arene = p-cymene or 4-phenyl-2-butanol; pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane, PR3 = PPh2(p-C6H4C2H4C8F17), PPh(p-C6H4C2H4C8F17)(2), P(p-C6H4C2H4C6F13)(3), PPh3 or P(p-C6H4F)(3)) have been prepared and characterized by spectroscopic methods. The structure of [Ru(eta(6)-p-cymene)(pta)Cl(P(p-C6H4F)(3))]BF4 has also been established in the solid state by X-ray crystallography. The cytotoxicities of the compounds were determined in the A2780 and A2780 cisplatin-resistant cell lines revealing that the fluorinated phosphines significantly increase antiproliferative activity relative to their bis-chloride precursors. Two of the complexes were found to be thermoresponsive, that is, showing poor water solubility at 37 degrees C and good solubility at 42 degrees C, the temperature of a heated tumor, providing a method of tumor targeting. Incubation at 42 degrees C for 2 h resulted in improved cytotoxicities for two of the complexes.

  DOI：

  10.1021/ic9020433
• 作为试剂：
  描述：

  N-tert-butoxycarbonyl-2-(2-(methoxymethyloxy)phenyl)-2-oxo-ethylsulfonamide 、 N-甲基磺酰基氨基甲酸叔丁酯 在 双[4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-十七氟癸基)苯基]苯膦 、 bis[1H,1H,2H,2H,3H,3H-perfluoro]azodicarboxylate 作用下， 以 四氢呋喃 为溶剂， 反应 12.5h， 以85%的产率得到5'-amino-5'-N,N⁶-di-tert-butoxycarbonyl-5'-deoxy-2',3'-O-isopropylidene-5'-N-[(2-(2-(methoxymethyloxy)phenyl)-2-oxo-ethyl)sulfonyl]adenosine
  参考文献：
  名称：

  Antibacterial Agents

  摘要：

  这项发明提供了化合物的公式(I)及其盐：R1-L-R2—B，其中R1、L、R2和B具有本文中定义的任何值，以及包含这种化合物的组合物，以及包含这种化合物或盐的治疗方法。这些化合物可以阻断细菌中的铁载体产生，并可用作抗菌剂。

  公开号：

  US20080293666A1

文献信息

• Use of Perfluorinated Phosphines to Provide Thermomorphic Anticancer Complexes for Heat-Based Tumor Targeting
  作者：Anna K. Renfrew、Rosario Scopelliti、Paul J. Dyson

  DOI：10.1021/ic9020433

  日期：2010.3.1

  A series of compounds of general formula [Ru(eta(6)-arene)(pta)(PR3)Cl]BF4 (arene = p-cymene or 4-phenyl-2-butanol; pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane, PR3 = PPh2(p-C6H4C2H4C8F17), PPh(p-C6H4C2H4C8F17)(2), P(p-C6H4C2H4C6F13)(3), PPh3 or P(p-C6H4F)(3)) have been prepared and characterized by spectroscopic methods. The structure of [Ru(eta(6)-p-cymene)(pta)Cl(P(p-C6H4F)(3))]BF4 has also been established in the solid state by X-ray crystallography. The cytotoxicities of the compounds were determined in the A2780 and A2780 cisplatin-resistant cell lines revealing that the fluorinated phosphines significantly increase antiproliferative activity relative to their bis-chloride precursors. Two of the complexes were found to be thermoresponsive, that is, showing poor water solubility at 37 degrees C and good solubility at 42 degrees C, the temperature of a heated tumor, providing a method of tumor targeting. Incubation at 42 degrees C for 2 h resulted in improved cytotoxicities for two of the complexes.