N3-[3-Methoxy-4-(5-oxazolyl)phenyl]-1-(3-nitrophenyl)-1H-1,2,4-triazole-3,5-diamine | 267645-10-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N3-[3-Methoxy-4-(5-oxazolyl)phenyl]-1-(3-nitrophenyl)-1H-1,2,4-triazole-3,5-diamine
• 英文别名: 3-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-1-(3-nitrophenyl)-1,2,4-triazole-3,5-diamine
• CAS: 267645-10-3
• 化学式: C₁₈H₁₅N₇O₄
• 分子量: 393.362
• InChiKey: OPDBFHCUSHADPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  150
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME<br/>[FR] COMPOSES DERIVES D'UN NOYAU AMINE INHIBITEURS DE L'ENZYME IMPDH
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2000025780A1

  公开（公告）日：2000-05-11

  The present invention discloses the identification of the novel inhibitors of IMPDH (inosine-5'-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH mediated diseases, such as transplant rejection and autoimmune diseases.

  本发明揭示了IMPDH（鸟苷-5'-单磷酸脱氢酶）的新型抑制剂的鉴定。本文所披露的化合物和药物组合物对于治疗或预防IMPDH介导的疾病，如移植排斥和自身免疫疾病，是有用的。
• EP1126843A4
  申请人：——

  公开号：EP1126843A4

  公开（公告）日：2005-06-15
• COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP1126843A1

  公开（公告）日：2001-08-29
• Metabolism-modulating agents and uses therefor
  申请人：Whitehead Paul Jonathan

  公开号：US20060106097A1

  公开（公告）日：2006-05-18

  The present invention is directed to methods and agents for modulating adipogenesis. More particularly, the present invention relates to molecules that modulate the level or functional activity of inosine-5′ monophosphate dehydrogenase (IMPDH) and to their use in modulating the accumulation of lipids in adipocytes and/or the differentiation of preadipocytes to adipocytes for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.
• US7915255B2
  申请人：——

  公开号：US7915255B2

  公开（公告）日：2011-03-29