4-[(E)-3-(7-methoxy-3-methyl-4-oxo-2-phenylchromen-8-yl)-3-oxoprop-1-enyl]benzonitrile

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 4-[(E)-3-(7-methoxy-3-methyl-4-oxo-2-phenylchromen-8-yl)-3-oxoprop-1-enyl]benzonitrile
• 化学式: C₂₇H₁₉NO₄
• 分子量: 421.4
• InChiKey: KYSINLVQQUGFHL-WYMLVPIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  76.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Novel chalcones
  申请人：——

  公开号：US20030055056A1

  公开（公告）日：2003-03-20

  The present invention discloses new and useful compounds including methyl p-hydroxyphenyllactate, its analogues, chemical derivatives and chemically related compounds and their use as antitumor and immune suppressive agents, as inhibitors of proliferative cell growth and as prophylactic agents to inhibit and prevent cancer and non-malignant cell growth.

  本发明揭示了新的有用化合物，包括甲基对羟基苯乳酸酯、其类似物、化学衍生物和化学相关化合物，以及它们作为抗肿瘤和免疫抑制剂、抑制增殖细胞生长的剂和预防癌症和非恶性细胞生长的预防剂的用途。
• NOVEL CHALCONES
  申请人：INDENA S.p.A.

  公开号：EP1212315B1

  公开（公告）日：2003-03-26
• US6620842B2
  申请人：——

  公开号：US6620842B2

  公开（公告）日：2003-09-16
• [EN] NOVEL CHALCONES<br/>[FR] NOUVELLES CHALCONES
  申请人：INDENA SPA

  公开号：WO2001017988A1

  公开（公告）日：2001-03-15

  Disclosed are novel chalcone derivatives having Formula (I). The compounds possess antiproliferative activity, and are useful for the manufacture of a medicament for the treatment or prevention of neoplasms, particularly those located in the uterus, ovary or breast. The compounds of the invention may also be useful in the manufacture of a medicament for the treatment or prevention of menopausal disorders and osteoporosis.