1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(4-methoxynaphthalen-1-yl)urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-(4-methoxynaphthalen-1-yl)urea
• 英文别名: 1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-(4-methoxynaphthalen-1-yl)urea
• 化学式: C₂₆H₂₈N₄O₂
• 分子量: 428.534
• InChiKey: IANFRRHFTBSTBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS
  申请人：Cannizzaro Carina

  公开号：US20090247488A1

  公开（公告）日：2009-10-01

  The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本发明涉及磷取代的抗炎化合物、含有这种化合物的组合物、包括给药这种化合物的治疗方法，以及用于制备这种化合物的有用过程和中间体。
• Anti-inflammatory medicaments
  申请人：Flynn Daniel L.

  公开号：US20090105230A1

  公开（公告）日：2009-04-23

  Novel compounds and methods of using those compounds for the treatment of inflammatory conditions are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein comprises the step of contacting the kinase protein with the novel compounds.

  提供了治疗炎症病症的新化合物及使用这些化合物的方法。在一个优选实施例中，调节p38激酶蛋白的激活状态包括将该激酶蛋白与新化合物接触。
• KINASE INHIBITORY PHOSPHONATE ANALOGS
  申请人：Cannizzaro Carina

  公开号：US20090181930A1

  公开（公告）日：2009-07-16

  The invention is related to phosphorus substituted kinase inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  该发明涉及磷取代的激酶抑制剂化合物，含有这种化合物的组合物，包括给予这种化合物的治疗方法，以及用于制备这种化合物的有用过程和中间体。
• Aromatic heterocyclic compounds as anti-inflammatory agents
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：EP1473292A1

  公开（公告）日：2004-11-03

  Novel aromatic heterocyclic compounds inhibit cytokines production involved in immunoregulation and inflammation such as interleukin-1 and tumor necrosis factor production. The compounds are therefore useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.

  新型芳香杂环化合物可抑制参与免疫调节和炎症反应的细胞因子的产生，如白细胞介素-1 和肿瘤坏死因子的产生。因此，这些化合物可用于治疗涉及炎症（如慢性炎症性疾病）的疾病或病理状况的药物组合物中。
• Aromatic heterocyclic compounds and their use as anti-inflammatory agents
  申请人：——

  公开号：US20010039290A1

  公开（公告）日：2001-11-08

  Novel aromatic heterocyclic compounds inhibit cytokines production involved in immunoregulation and inflammation such as interleukin-1 and tumor necrosis factor production. The compounds are therefore useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.

  新型芳香杂环化合物可抑制参与免疫调节和炎症反应的细胞因子的产生，如白细胞介素-1 和肿瘤坏死因子的产生。因此，这些化合物可用于治疗涉及炎症（如慢性炎症性疾病）的疾病或病理状况的药物组合物中。