methyl 2-[3-chloro-4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-5-yl}methoxy)phenyl]acetate | 317318-53-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: methyl 2-[3-chloro-4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-5-yl}methoxy)phenyl]acetate
• 英文别名: Methyl 2-[3-chloro-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-oxazol-5-yl]methoxy]phenyl]acetate
• CAS: 317318-53-9
• 化学式: C₂₁H₁₇ClF₃NO₄
• 分子量: 439.818
• InChiKey: BDRKCQMYMBYQCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  61.6
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Activator of PPAR delta
  申请人：——

  公开号：US20030203947A1

  公开（公告）日：2003-10-30

  Compounds of Formula (I) are disclosed. These compounds include selective activators of human PPAR delta.

  公式（I）的化合物已被披露。这些化合物包括人类PPAR delta的选择性激活剂。
• [EN] THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE<br/>[FR] DERIVES DE THIAZOL ET D'OXAZOLE ET UTILISATION PHARMACEUTIQUE DE CEUX-CI
  申请人：GLAXO GROUP LTD

  公开号：WO2001000603A1

  公开（公告）日：2001-01-04

  Compounds of Formula (I) are disclosed. These compounds include selective activators of human PPAR delta.

  本发明公开了化学式(I)的化合物。这些化合物包括选择性激活人类PPAR delta的激动剂。
• Compositions and methods for promoting intestinal stem cell and/or non-stem progenitor cell function
  申请人：Whitehead Institute for Biomedical Research

  公开号：US10426757B2

  公开（公告）日：2019-10-01

  Disclosed herein are novel methods and compositions useful for promoting intestinal stem cell function. The methods and compositions are particularly useful for stimulating the proliferation of and/or self-renewal of intestinal stem cells, as well as for minimizing, preventing, or ameliorating cellular damage resulting from incidental or accidental exposure to radiation (e.g., cancer radiation therapy).

  本文公开了有助于促进肠道干细胞功能的新型方法和组合物。这些方法和组合物特别适用于刺激肠道干细胞的增殖和/或自我更新，以及最大限度地减少、预防或改善因偶然或意外暴露于辐射（如癌症放射治疗）而造成的细胞损伤。
• THIAZOLE AND OXAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE
  申请人：GLAXO GROUP LIMITED

  公开号：EP1189895A1

  公开（公告）日：2002-03-27
• COMPOSITIONS AND METHODS FOR PROMOTING INTESTINAL STEM CELL AND/OR NON-STEM PROGENITOR CELL FUNCTION
  申请人：Whitehead Institute for Biomedical Research

  公开号：US20170258772A1

  公开（公告）日：2017-09-14

  Disclosed herein are novel methods and compositions useful for promoting intestinal stem cell function. The methods and compositions are particularly useful for stimulating the proliferation of and/or self-renewal of intestinal stem cells, as well as for minimizing, preventing, or ameliorating cellular damage resulting from incidental or accidental exposure to radiation (e.g., cancer radiation therapy).