5-fluoro-4-oxo-3-[[(2S,11S)-12-oxo-11-(phenylmethoxycarbonylamino)-1-azatricyclo[6.4.1.04,13]trideca-4,6,8(13)-triene-2-carbonyl]amino]pentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 5-fluoro-4-oxo-3-[[(2S,11S)-12-oxo-11-(phenylmethoxycarbonylamino)-1-azatricyclo[6.4.1.04,13]trideca-4,6,8(13)-triene-2-carbonyl]amino]pentanoic acid
• 化学式: C₂₆H₂₆FN₃O₇
• 分子量: 511.5
• InChiKey: ACMIMPKMLMDEEA-WMEOFMBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Caspase inhibitor prodrugs
  申请人：Mortimore Michael

  公开号：US20080199454A1

  公开（公告）日：2008-08-21

  The present invention relates to compounds of formula I which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. This invention further relates to pharmaceutical compositions comprising these compounds, which are particularly well-suited for treatment of caspase-mediated diseases, including inflammatory and degenerative diseases. This invention further relates to methods for preparing compounds of this invention.
• US7410956B2
  申请人：——

  公开号：US7410956B2

  公开（公告）日：2008-08-12
• US9956260B1
  申请人：——

  公开号：US9956260B1

  公开（公告）日：2018-05-01
• [EN] PHOSPHOLIPIDS AS CASPASE INHIBITOR PRODRUGS<br/>[FR] PHOSPHOLIPIDES TELS QUE DES PROMEDICAMENTS INHIBITEURS DE CASPASES
  申请人：VERTEX PHARMA

  公开号：WO2003068242A1

  公开（公告）日：2003-08-21

  The present invention relates to compounds of formula (I): which are prodrugs of caspase inhibitors and pharmaceutically acceptable salts thereof. This invention further relates to the release of caspase inhibitors from these compounds through selective bond cleavage. This invention further relates to pharmaceutical compositions comprising these compounds, which are particularly well-suited for treatment of caspase-mediated diseases, including inflammatory and degenerative diseases. This invention further relates to methods for preparing compounds of this invention.