3-Fluoro-5-[5-(1-methylpyrazol-3-yl)tetrazol-2-yl]benzonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-Fluoro-5-[5-(1-methylpyrazol-3-yl)tetrazol-2-yl]benzonitrile
• 化学式: C₁₂H₈FN₇
• 分子量: 269.24
• InChiKey: CUDSULYLOCNKPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  85.2
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Heteroaryl substituted tetrazole modulators of metabotrophic glutamate receptor-5
  申请人：——

  公开号：US20040186295A1

  公开（公告）日：2004-09-23

  Tetrazole compounds substituted directly, or by a bridge, with a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl, are mGluR5 modulators useful in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, and panic, as well as in the treatment of pain and other diseases.

  直接或通过桥连接到含有N的杂环基团，的四唑化合物是mGluR5调节剂，可用于治疗精神和情绪障碍，如精神分裂症、焦虑、抑郁和恐慌，以及疼痛和其他疾病的治疗。
• HETEROARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5
  申请人：Merck & Co., Inc.

  公开号：EP1434773B1

  公开（公告）日：2008-05-21
• US7253190B2
  申请人：——

  公开号：US7253190B2

  公开（公告）日：2007-08-07
• [EN] TREATMENT OF OBESITY AND OTHER DISORDERS ASSOCIATED WITH EXCESSIVE FOOD INTAKE<br/>[FR] TRAITEMENT DE L'OBESITE ET D'AUTRES TROUBLES ASSOCIES A UNE CONSOMMATION ALIMENTAIRE EXCESSIVE
  申请人：MERCK & CO INC

  公开号：WO2004030637A2

  公开（公告）日：2004-04-15

  Modulators of metabotropic glutamate receptor-5 (mGluR5) are useful in treating disorders associated with excessive food intake, including obesity and obesity-related disorders. In particular, mGluR5 antagonists of structural formulae IA-IF are useful in treating these conditions, either as single agents or in combination with other compounds useful for treating obesity.