3-(5-p-tolyl-[1,2,4]oxadiazol-3-yl)-benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(5-p-tolyl-[1,2,4]oxadiazol-3-yl)-benzoic acid
• 英文别名: 3-[5-(4-Methylphenyl)-1,2,4-oxadiazol-3-yl]benzoic acid
• 化学式: C₁₆H₁₂N₂O₃
• 分子量: 280.283
• InChiKey: OGJOMWPGJJVKGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  76.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
  申请人：——

  公开号：US20040204461A1

  公开（公告）日：2004-10-14

  Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

  本专利揭示了一种1,2,4-噁二唑苯甲酸化合物的新颖方法，以及使用方法和包含1,2,4-噁二唑苯甲酸衍生物的药物组合物。该方法包括治疗或预防通过调控过早翻译终止或无义介导的mRNA降解而改善的疾病的方法，或改善与之相关的一个或多个症状的方法。
• [EN] 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE<br/>[FR] COMPOSES D'ACIDE BENZOIQUE 1,2,4-OXADIAZOLE ET UTILISATION DE CEUX-CI DANS LA SUPPRESSION NON-SENS ET LE TRAITEMENT DE MALADIES
  申请人：PTC THERAPEUTICS INC

  公开号：WO2004091502A2

  公开（公告）日：2004-10-28

  Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

  本发明揭示了1,2,4-噁二唑苯甲酸化合物的小说1,2,4-噁二唑苯甲酸衍生物的使用方法和包括1,2,4-噁二唑苯甲酸衍生物的制药组合物。所述方法包括治疗或预防通过调节过早翻译终止或无意义介导的mRNA降解改善的疾病，或改善与之相关的一个或多个症状的方法。
• Substituted 1,2,4-oxadiazoles, compositions and methods of use
  申请人：Karp Mitchell Gary

  公开号：US20060148863A1

  公开（公告）日：2006-07-06

  Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

  本发明公开了1,2,4-噁二唑苯甲酸化合物、使用方法和包含1,2,4-噁二唑苯甲酸衍生物的制药组合物。该方法包括治疗或预防通过调节过早翻译终止或无意义介导的mRNA降解所缓解的疾病的方法，或缓解与之相关的一个或多个症状的方法。
• 3-[5-(2-Fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid, compositions, and methods for the use thereof
  申请人：Karp Mitchell Gary

  公开号：US20060148864A1

  公开（公告）日：2006-07-06

  Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

  本发明公开了一种1,2,4-噁二唑苯甲酸化合物的小说1,2,4-噁二唑苯甲酸衍生物的使用方法和制药组合物。该方法包括治疗或预防通过调节过早翻译终止或无意义介导的mRNA降解而改善的疾病的方法，或改善与之相关的一个或多个症状的方法。
• 1,2,4-Oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease
  申请人：Karp Mitchell Gary

  公开号：US20050164973A1

  公开（公告）日：2005-07-28

  Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

  本发明公开了一种1,2,4-噁二唑苯甲酸化合物的小说1,2,4-噁二唑苯甲酸衍生物的使用方法和包含1,2,4-噁二唑苯甲酸衍生物的制药组合物。该方法包括治疗或预防通过调节过早翻译终止或无意义介导的mRNA降解而改善的疾病的方法，或改善与之相关的一个或多个症状的方法。