(3Z)-3-(5-methoxy-2,3-dihydroinden-1-ylidene)-1H-indol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (3Z)-3-(5-methoxy-2,3-dihydroinden-1-ylidene)-1H-indol-2-one
• 化学式: C₁₈H₁₅NO₂
• 分子量: 277.3
• InChiKey: KNNMCPHJTBAEMW-VKAVYKQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity
  申请人：SUGEN, INC.

  公开号：US20030199510A1

  公开（公告）日：2003-10-23

  The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

  本发明涉及新型几何限制的2-吲哚酮及其生理上可接受的盐，可以调节蛋白激酶的活性，因此预计在预防和治疗蛋白激酶相关的细胞疾病，如癌症方面有用。
• GEOMETRICALLY RESTRICTED 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY
  申请人：Sugen, Inc.

  公开号：EP1117397A1

  公开（公告）日：2001-07-25
• US6525072B1
  申请人：——

  公开号：US6525072B1

  公开（公告）日：2003-02-25
• US6642251B1
  申请人：——

  公开号：US6642251B1

  公开（公告）日：2003-11-04
• [EN] GEOMETRICALLY RESTRICTED 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY<br/>[FR] DERIVES DE 2-INDOLINONE A GEOMETRIE LIMITEE UTILISES EN TANT QUE MODULATEURS DE L'ACTIVITE DE LA PROTEINE KINASE
  申请人：SUGEN INC

  公开号：WO2000012084A1

  公开（公告）日：2000-03-09

  The present invention relates to novel geometrically restricted 2-indolinones and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.