3',4',6-trihydroxy-5,7,8-trimethoxyflavone | 84632-09-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3',4',6-trihydroxy-5,7,8-trimethoxyflavone
• 英文别名: 6,3',4'-trihydroxy-5,7,8-trimethoxyflavone；2-(3,4-Dihydroxyphenyl)-6-hydroxy-5,7,8-trimethoxychromen-4-one
• CAS: 84632-09-7
• 化学式: C₁₈H₁₆O₈
• 分子量: 360.32
• InChiKey: PHKIHRKCNFFHJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  3',4',6-tris(benzyloxy)-5,7,8-trimethoxyflavone 生成 3',4',6-trihydroxy-5,7,8-trimethoxyflavone
  参考文献：
  名称：

  Inhibitor of aldose reductase

  摘要：

  一种醛糖还原酶抑制剂，其有效成分为含有以下结构式的黄酮衍生物：##STR1## 其中R.sub.1为氢原子或羟基，R.sub.2为羟基或甲氧基，或其药学上可接受的盐，并含有药学上可接受的载体。该抑制剂可用于预防、减少或治疗糖尿病的并发症。

  公开号：

  US04532254A1

文献信息

• Compositions and methods for the treatment of diabetic neuropathy
  申请人：——

  公开号：US20020165207A1

  公开（公告）日：2002-11-07

  Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

  本发明公开了治疗糖尿病神经病变的组合物和方法。这些组合物包括一种促进神经生长因子合成的化合物、一种醛糖还原酶抑制剂和一种抗氧化剂的混合物，可选择配制在药学上可接受的载体中。这种活性剂组合能明显、有效地缓解糖尿病神经病变的症状，在某些情况下至少能部分恢复丧失的神经功能。此外，本发明的组合物以有效量用于治疗糖尿病神经病变时，不会表现出许多现有技术组合物用于治疗这种疾病的严重副作用。 第二方面，本发明公开了一种根据本发明的组合物治疗糖尿病神经病变的给药方法。在该方法中，在一段时间内定期施用有效量的本发明组合物，足以提供缓解糖尿病神经病变症状的有益效果，以及至少使受损的神经组织得到一定程度的恢复。
• Method and composition for the topical treatment of diabetic neuropathy
  申请人：——

  公开号：US20020115618A1

  公开（公告）日：2002-08-22

  A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment, In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recover of the damaged nerve tissues.

  本发明公开了一种治疗糖尿病神经病变的方法和组合物。该组合物由一种促进神经生长因子合成的化合物、一种醛糖还原酶抑制剂和一种抗氧化剂的冷复合混合物组成，并配制在一种药学上可接受的载体中。研究发现，这种活性剂的组合能明显、有效地缓解糖尿病神经病变的症状，在某些情况下至少能部分恢复丧失的神经功能。鉴于该领域的共识是，各种活性剂的有效组合尚未被证明对治疗糖尿病神经病变有效，本发明提供了令人惊讶和意想不到的效果。此外，本发明的外用组合物以有效量用于治疗糖尿病神经病变时，不会表现出许多现有技术中提出的用于治疗这种疾病的组合物的严重副作用、 第二方面，公开了一种局部使用本发明组合物治疗糖尿病神经病变的方法。在该方法中，将有效量的本发明组合物局部施用到受到糖尿病神经病变不利影响的身体部位，并定期施用一段时间，以达到缓解症状和至少恢复受损神经组织的有益效果。
• Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
  申请人：——

  公开号：US20030105027A1

  公开（公告）日：2003-06-05

  A nutritional supplement composition for the prevention, reduction or treatment of radiation injury due to exposure to ionizing radiation, including one or more compounds that regulates cell differentiation and/or cell proliferation, and one or more antioxidants, optionally formulated in a pharmaceutically acceptable carrier for an oral composition. The composition of the present invention may further include optional ingredients such as flavonoids, flavonoid derivatives, selenium, selenium compounds, anti-inflammatories, organic germanium, Korean ginseng, American ginseng, Siberian ginseng and B-complex vitamins. A method for the administration of an oral composition for the purpose of preventing, reducing or treating radiation injury involves orally administering an effective amount of a composition including one or more compounds that regulates cell differentiation and/or cell proliferation, and one or more antioxidants to a person before, during or after radiation exposure. A method for the topical administration of the composition in accordance with the present invention for the purpose of preventing, reducing or treating radiation injury involves topically administering an effective amount of the composition of the invention an area of skin, which has been or will be exposed to ionizing radiation. The compositions and methods can be employed to prevent, reduce or treat radiation injury caused by a wide variety of types of radiation exposure.

  一种用于预防、减少或治疗电离辐射照射引起的辐射损伤的营养补充组合物，包括一种或多种调节细胞分化和/或细胞增殖的化合物，以及一种或多种抗氧化剂，可选择配制在药学上可接受的载体中作为口服组合物。本发明的组合物可进一步包括任选成分，如类黄酮、类黄酮衍生物、硒、硒化合物、抗炎剂、有机锗、高丽参、花旗参、西伯利亚参和 B 复合维生素。一种以预防、减少或治疗辐射损伤为目的的口服组合物给药方法，包括在辐照前、辐照期间或辐照后向人口服有效量的组合物，其中包括一种或多种调节细胞分化和/或细胞增殖的化合物，以及一种或多种抗氧化剂。为了预防、减少或治疗辐射损伤，局部施用本发明组合物的方法包括局部施用有效量的本发明组合物到已经或将要暴露于电离辐射的皮肤区域。本发明的组合物和方法可用于预防、减少或治疗由各种类型的辐射照射造成的辐射损伤。
• Composition and method for prevention, reduction and treatment of radiation dermatitis
  申请人：——

  公开号：US20030103953A1

  公开（公告）日：2003-06-05

  A composition for the preventing, reducing or treating radiation dermatitis includes a mixture of one or more compounds that regulates cell differentiation and/or cell proliferation, and one or more antioxidants formulated in a pharmaceutically acceptable carrier. The composition of the present invention may further include a flavonoid. A method for the topical administration of the composition in accordance with the present invention for the purpose of preventing, reducing or treating radiation dermatitis involves topically administering an effective amount of the composition of the invention an area of skin which has been or will be exposed to radiation. The composition and method can be employed to prevent, reduce or treat radiation dermatitis caused by a wide variety of types of radiation exposure and is particularly useful for the prevention, reduction or treatment of radiation recall dermatitis.

  一种用于预防、减轻或治疗辐射性皮炎的组合物包括一种或多种调节细胞分化和/或细胞增殖的化合物的混合物，以及一种或多种配制在药学上可接受的载体中的抗氧化剂。本发明的组合物可进一步包括类黄酮。为预防、减轻或治疗辐射性皮炎而局部施用符合本发明的组合物的方法包括局部施用有效量的本发明组合物到已经或将要暴露于辐射的皮肤区域。本发明的组合物和方法可用于预防、减轻或治疗由各种类型的辐射照射引起的辐射性皮炎，尤其适用于预防、减轻或治疗辐射回忆性皮炎。
• Oral compositions and methods for prevention, reduction and treatment of radiation injury
  申请人：——

  公开号：US20030103954A1

  公开（公告）日：2003-06-05

  An oral composition for the prevention, reduction or treatment of radiation injury including one or more compounds that regulates cell differentiation and/or cell proliferation, and one or more antioxidants, optionally formulated in a pharmaceutically acceptable carrier for an oral composition. The composition of the present invention may further include optional ingredients such as flavonoids, flavonoid derivatives, selenium, selenium compounds, anti-inflammatories, organic germanium, Korean ginseng, American ginseng, Siberian ginseng and B-complex vitamins. A method for the administration of an oral composition for the purpose of preventing, reducing or treating radiation injury involves orally administering an effective amount of a composition including one or more compounds that regulates cell differentiation and/or cell proliferation, and one or more antioxidants to a person before, during or after radiation exposure. The compositions and methods can be employed to prevent, reduce or treat radiation injury caused by a wide variety of types of radiation exposure.

  一种用于预防、减少或治疗辐射损伤的口服组合物，包括一种或多种调节细胞分化和/或细胞增殖的化合物，以及一种或多种抗氧化剂，可选择配制在药学上可接受的载体中作为口服组合物。本发明的组合物可进一步包括任选成分，如类黄酮、类黄酮衍生物、硒、硒化合物、抗炎剂、有机锗、高丽参、花旗参、西伯利亚参和 B 复合维生素。一种以预防、减少或治疗辐射损伤为目的的口服组合物给药方法，包括在辐照前、辐照期间或辐照后向人口服有效量的组合物，其中包括一种或多种调节细胞分化和/或细胞增殖的化合物，以及一种或多种抗氧化剂。这些组合物和方法可用于预防、减少或治疗由各种类型的辐照造成的辐射损伤。