8-(2-fluorophenyl)-2-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-3-phenyl-imidazo[1,2-d][1,2,4]triazine | 327985-36-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 8-(2-fluorophenyl)-2-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-3-phenyl-imidazo[1,2-d][1,2,4]triazine
• 英文别名: 8-(2-Fluorophenyl)-2-[(2-methyl-1,2,4-triazol-3-yl)methoxy]-3-phenylimidazo[1,2-d][1,2,4]triazine
• CAS: 327985-36-4
• 化学式: C₂₁H₁₆FN₇O
• 分子量: 401.403
• InChiKey: NOIFTZSXWCKKIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  83
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1212324A1

  公开（公告）日：2002-06-12
• US6608062B1
  申请人：——

  公开号：US6608062B1

  公开（公告）日：2003-08-19
• [EN] IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS<br/>[FR] DERIVES D'IMIDAZO-TRIAZINE UTILES COMME LIGANDS DE RECEPTEURS GABA
  申请人：MERCK SHARP & DOHME

  公开号：WO2001014377A1

  公开（公告）日：2001-03-01

  A class of substituted imidazo[1,2-d][1,2,4]triazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 8-position, a substituted alkoxy moiety at the 2-position, a range of substituents at the 3-position and an optional alkyl or cycloalkyl substituent at the 5-position, are selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.