N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl][(4-chlorophenyl)amino]carboxamid | 247038-06-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl][(4-chlorophenyl)amino]carboxamid
• 英文别名: 1-[3-(4-Bromo-1-methylpyrazol-3-yl)phenyl]-3-(4-chlorophenyl)urea
• CAS: 247038-06-8
• 化学式: C₁₇H₁₄BrClN₄O
• 分子量: 405.681
• InChiKey: WUXIUWVNTUGRFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  59
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof
  申请人：Behan P. Dominic

  公开号：US20050119182A1

  公开（公告）日：2005-06-02

  Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT2A and human 5-HT 2C receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT2A receptors. Yet further disclosed is a new class of compounds which act at the 5HT2A receptors.

  本文披露的是人类5-HT2A和人类5-HT2C受体的非内源性、组成性激活形式，以及使用这些受体筛选候选化合物的用途。此外，本文还披露了通过筛选方法鉴定出作用于5HT2A受体的候选化合物。还披露了一类在5HT2A受体上起作用的新化合物。
• Non-endogeneous, constitutively activated human serotonin receptors and small molecule modualtors thereof
  申请人：——

  公开号：US20030224442A1

  公开（公告）日：2003-12-04

  Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT 2A and human 5-HT 2C receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT 2A receptors. Yet further disclosed is a new class of compounds which act at the 5HT 2A receptors.

  本文披露了非内源性、常规激活的人类5-HT2A和人类5-HT2C受体形式，以及使用这些受体筛选候选化合物的用途。此外，本文还披露了通过筛选方法鉴定出的作用于5-HT2A受体的候选化合物。更进一步地，本文还披露了一类在5-HT2A受体上发挥作用的新型化合物。
• NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF
  申请人：Behan Dominic P.

  公开号：US20090076254A1

  公开（公告）日：2009-03-19

  Disclosed herein are non-endogenous, constitutively activated forms of the human 5-HT 2A and human 5-HT 2C receptors and uses of such receptors to screen candidate compounds. Further disclosed herein are candidate compounds identified by the screening method which act at the 5HT 2A receptors. Yet further disclosed is a new class of compounds which act at the 5HT 2A receptors.

  本文披露了人类5-HT2A和人类5-HT2C受体的非内源性、持续激活的形式，以及使用这些受体筛选候选化合物的用途。此外，本文还披露了通过筛选方法识别出的作用于5HT2A受体的候选化合物。还披露了一类在5HT2A受体上起作用的新化合物。
• US6107324A
  申请人：——

  公开号：US6107324A

  公开（公告）日：2000-08-22
• US6140509A
  申请人：——

  公开号：US6140509A

  公开（公告）日：2000-10-31