2-[2-(3,5-dimethylphenyl)-3-[2-(4-pyridin-4-ylbutylamino)ethyl]imidazo[1,2-a]pyridin-6-yl]-2-methyl-N,N-bis(2-methylpropyl)propanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[2-(3,5-dimethylphenyl)-3-[2-(4-pyridin-4-ylbutylamino)ethyl]imidazo[1,2-a]pyridin-6-yl]-2-methyl-N,N-bis(2-methylpropyl)propanamide
• 化学式: C₃₈H₅₃N₅O
• 分子量: 595.9
• InChiKey: SCLYRAWJWXXGSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  44
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  62.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] COMPOUNDS<br/>[FR] COMPOSES
  申请人：ASTRAZENECA AB

  公开号：WO2002066477A2

  公开（公告）日：2002-08-29

  The present invention relates to compounds of formula I which are antagonists of gonadotropin releasing hormone (GnRH) activity. The invention also relates to pharmaceutical formulations, the use of a compound of the present invention in the manufacture of a medicament, a method of therapeutic treatment using such a compound and processes for producing the compounds wherein: - R1, R2 and R3 are as defined in the description; and ring A is optionally further substituted.