6-[2-(3-Methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propan-2-ylpyridazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-[2-(3-Methoxyphenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propan-2-ylpyridazin-3-one
• 化学式: C₂₁H₂₀N₄O₂
• 分子量: 360.4
• InChiKey: FUFXQEKJVLPYCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  59.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] PYRAZOLOPYRIDINE AS ADENOSINE ANTAGONISTS<br/>[FR] COMPOSES DE PYRAZOLOPYRIDINE UTILES EN TANT QU'ANTAGONISTES D'ADENOSINE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2000024742A1

  公开（公告）日：2000-05-04

  A pyrazolopyridine compound of formula (I),: wherein R1 is a phenyl having one or two substituent(s) selected from the group consisting of halogen, lower alkyl, halo(lower)alkyl, hydroxy, lower alkoxy and ar(lower)alkoxy; and R2 is a hydrogen or a lower alkyl, or a salt thereof. The pyrazolopyridine compound (I) and a salt thereof of the present invention are adenosine antagonists and are useful for the prevention and/or treatment of depression, dementia (e.g. Alzheimer's disease, cerebrovascular dementia, dementia accompanying Parkinson's disease, etc.), Parkinson's disease, anxiety, pain, cerebrovascular disease (e.g. stroke, etc.), heart failure, and the like.