2-(1H-imidazol-5-yl)cyclopropane-1-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(1H-imidazol-5-yl)cyclopropane-1-carbonitrile
• 化学式: C₇H₇N₃
• mdl: MFCD19226618
• 分子量: 133.15
• InChiKey: ZRPSVOSIIGRPIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  52.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Novel alicyclic imidazoles as H3 agents
  申请人：——

  公开号：US20020042400A1

  公开（公告）日：2002-04-11

  Alicyclic imidazole compounds; pharmaceutically active compositions containing such compounds; and the use of such compounds in formulations for the control or prevention of disease states in which histamine H 3 receptors are involved, such as allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper- and hypo-motility of the gastro-intestinal tract, cardiovascular disease, hypo- and hyper-activity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines are disclosed.

  本文介绍了脂环咪唑化合物、含有这些化合物的药用组合物以及在控制或预防涉及组胺H3受体的疾病状态（如过敏、炎症、低血压、青光眼、睡眠障碍、胃肠道高低动力状态、心血管疾病、中枢神经系统低高活性、阿尔茨海默病、精神分裂症、肥胖症和偏头痛等）的制剂中使用此类化合物的方法。
• Novel alicylic imidazoles as H3 agents
  申请人：——

  公开号：US20040029943A1

  公开（公告）日：2004-02-12

  Alicyclic imidazole compounds; pharmaceutically active compositions containing such compounds; and the use of such compounds in formulations for the control or prevention of disease states in which histamine H 3 receptors are involved, such as allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper- and hypo-motility of the gastro-intestinal tract, cardiovascular disease, hypo- and hyper-activity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines are disclosed.

  本发明涉及脂环型咪唑化合物；含有这种化合物的药物活性组合物；以及在制剂中使用这种化合物来控制或预防组织胺H3受体参与的疾病状态，例如过敏、炎症、低血压、青光眼、睡眠障碍、胃肠道过度和过度活动状态、心血管疾病、中枢神经系统的低活性和高活性、阿尔茨海默病、精神分裂症、肥胖症和偏头痛。
• NOVEL ALICYCLIC IMIDAZOLES AS H 3 AGENTS
  申请人：GLIATECH, INC.

  公开号：EP1313470A1

  公开（公告）日：2003-05-28
• EP1313470A4
  申请人：——

  公开号：EP1313470A4

  公开（公告）日：2005-02-16
• US6794405B2
  申请人：——

  公开号：US6794405B2

  公开（公告）日：2004-09-21