2-Ethyl-6-(2-phenylpyrazolo[1,5-a]pyrazin-3-yl)pyridazin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Ethyl-6-(2-phenylpyrazolo[1,5-a]pyrazin-3-yl)pyridazin-3-one
• 化学式: C₁₈H₁₅N₅O
• 分子量: 317.3
• InChiKey: BLQWHNJPDIYHQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1244669A1

  公开（公告）日：2002-10-02
• [EN] PYRAZOLOPYRAZINES AND THEIR USE AS ADENOSINE ANTAGONISTS<br/>[FR] PYRAZOLOPYRAZINES ET LEUR UTILISATION COMME ANTAGONISTES VIS-A-VIS DE L'ADENOSINE
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2001040230A1

  公开（公告）日：2001-06-07

  A pyrazolopyrazine compound of formula (I): wherein R1 is aryl which may have one or more suitable substituent(s); and R2 is hydrogen; lower alkyl; lower alkenyl; cyclo(lower)alkyl; heteromonocyclic group; lower alkyl substituted with one or more substituent(s) selected from the group consisting of cyclo(lower)alkyl, halogen, cyano, aryl and heteromonocyclic group, or a salt thereof. The pyrazolopyrazine compound (I) and salt thereof of the present invention are adenosine antagonists and are useful for the prevention and/or treatment of depression, dementia (e.g. Alhzheimer's disease, cerebrovascular dementia, dementia accompanying Parkinson's disease, etc.), Parkinson's disease, anxiety, pain, cerebrovascular disease (e.g. stroke, etc.), heart failure and the like.