phenylsulfonyl-2-azetidinone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: phenylsulfonyl-2-azetidinone
• 英文别名: 1-(Benzenesulfonyl)azetidin-2-one
• 化学式: C₉H₉NO₃S
• 分子量: 211.241
• InChiKey: VKIOSFOKYKUOIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenylsulfonyl-2-azetidinone 、 乙烯基溴化镁 以 四氢呋喃 为溶剂， 反应 1.17h， 以62%的产率得到4-乙烯氮杂啶-2-酮
  参考文献：
  名称：

  [EN] 2-CYANOPYRROLES AND THEIR ANALOGUES AS DDP-IV INHIBITORS
  [FR] 2-CYANOPYRROLES ET LEURS ANALOGUES EN TANT QU'INHIBITEURS DE DIPEPTIDYLPEPTIDASE-IV (DP-IV)

  摘要：

  本发明涉及具有以下式I的治疗活性和选择性抑制剂的酶DPP-IV。此外，本发明还涉及包含这些化合物的药物组合物，以及利用这些化合物制造用于治疗与DPP-IV使蛋白质失活相关的疾病的药物，例如2型糖尿病和肥胖症。

  公开号：

  WO2004089362A1

文献信息

• Reactive liquid polymer crosslinking agent and process for preparation
  申请人：——

  公开号：US20030168629A1

  公开（公告）日：2003-09-11

  A reactive liquid crosslinking agent for use in the preparation of polymeric substances. The crosslinking agent comprises a substituted 1,3,5 Triazine reacted with water, an acid alkyl sulfonate and/or phosphonate and a solidifying modifier containing an hydroxyl functional group. The reactive liquid polymer crosslinking agent has a solids content between 20-99% solids. The reactive liquid crosslinking agents (RLPC's) are useful as modifiers in the preparation of polymeric compounds which are suitable for one-component self-crosslinking adhesives, coatings and polymers used in optics, textiles, composites, casting and molding. RLPC systems containing from 1-30% RLPC provide fast single package thermosetting polymeric compounds with enhanced properties such as chemical, heat and abrasion resistance.
• US4882429A
  申请人：——

  公开号：US4882429A

  公开（公告）日：1989-11-21
• [EN] REACTIVE LIQUID POLYMER CROSSLINKING AGENT AND PROCESS FOR PREPARATION<br/>[FR] AGENT DE RETICULATION POLYMERE LIQUIDE, REACTIF ET PROCEDE DE PREPARATION
  申请人：LCB WORLDWIDE INC

  公开号：WO2003050094A1

  公开（公告）日：2003-06-19

  A reactive liquid crosslinking agent for use in the preparation of polymeric substances. The crosslinking agent comprises a substituted 1,3,5 Triazine reacted with water, an acid alkyl sulfonate and/or phosphonate and a solidifying modifier containing an hydroxyl functional group. The reactive liquid polymer crosslinking agent has a solids content between 20-99 % solids. The reactive liquid crosslinking agents (RLPC's) are useful as modifiers in the preparation of polymeric compounds which are suitable for one-component self-crosslinking adhesives, coatings and polymers used in optics, textiles, composites, casting and molding. RLPC systems containing from 1-30 % RLPC provide fast single package thermosetting polymeric compounds with enhanced properties such as chemical, heat and abrasion resistance.