2-[[5-[4-[[6-(Butoxycarbonylamino)indol-1-yl]methyl]-3-methoxyphenyl]tetrazol-1-yl]methyl]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[[5-[4-[[6-(Butoxycarbonylamino)indol-1-yl]methyl]-3-methoxyphenyl]tetrazol-1-yl]methyl]benzoic acid
• 化学式: C₃₀H₃₀N₆O₅
• 分子量: 554.6
• InChiKey: LOUQWXGCGSPNSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  41
• 可旋转键数：
  12
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• BENZOIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS
  申请人：AstraZeneca AB

  公开号：EP1210339A1

  公开（公告）日：2002-06-05
• US6787556B1
  申请人：——

  公开号：US6787556B1

  公开（公告）日：2004-09-07
• [EN] BENZOIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS<br/>[FR] DERIVES D'ACIDE BENZOIQUE POUR LE TRAITEMENT DU DIABETE SUCRE
  申请人：ASTRAZENECA AB

  公开号：WO2001012612A1

  公开（公告）日：2001-02-22

  Benzoic acid derivatives of formula (I), which act as peroxisome proliferator activated receptor (PPAR) agonists, in particular states of insulin resistance including type 2 gamma receptors (PPAR), and so are useful therapeutically in the treatment of diabetes mellitus. In said formula Q, X, Y and Z are either -CR?a=, -CRb=CRc¿- or -N=; where R?a, Rb and Rc¿ are independently selected from hydrogen, halo or a bond, such that together with the nitrogen atom to which Y and Z are attached, they form a five or six-membered aromatic ring; R?1 and R3¿ are independently selected from C¿1-3?alkyl, halo, haloC1-3alkyl, C1-3alkoxy, or haloC1-3alkoxy; n and m are independently selected from 0, 1 or 2; A is an alkylene, alkenylene or alkynylene chain optionally interposed by a heteroatom; and R?2¿ is an optionally substituted aryl, optionally substituted heterocyclyl or optionally substituted cycloalkyl moiety.