1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-[2-(1-phenylethylamino)pyrimidin-4-yl]ethoxy]naphthalen-1-yl]urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[5-Tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-[2-[2-(1-phenylethylamino)pyrimidin-4-yl]ethoxy]naphthalen-1-yl]urea
• 化学式: C₃₉H₄₁N₇O₂
• 分子量: 639.8
• InChiKey: NVIBGZFJFJNVSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  48
• 可旋转键数：
  11
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• 1,4-DISUBSTITUTED BENZOFUSED CYCLOALKYL UREA COMPOUNDS USEFUL IN TREATING CYTOKINE MEDIATED DISEASES
  申请人：Boehringer Ingelheim Pharmaceuticals Inc.

  公开号：EP1480973B1

  公开（公告）日：2008-02-13
• US7041669B2
  申请人：——

  公开号：US7041669B2

  公开（公告）日：2006-05-09
• [EN] 1,4-DISUBSTITUTED BENZOFUSED CYCLOALKYL UREA COMPOUNDS USEFUL IN TREATING CYTOKINE MEDIATED DISEASES<br/>[FR] COMPOSES DE CYCLOALKYLE UREE BENZOFUSIONNES A DISUBSTITUTION EN POSITION 1,4 UTILES DANS LE TRAITEMENT DE MALADIES MEDIEES PAR LA CYTOKINE
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2003072569A1

  公开（公告）日：2003-09-04

  Disclosed are 1,4-disubstituted benzo-fused urea compounds of formula (I) wherein AR, X A, L, and Q of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and compositons, and pharmaceutical compositions comprising these compounds.