2-(2,3-Diamino-4-methyl-1,3-thiazol-3-ium-5-yl)ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2,3-Diamino-4-methyl-1,3-thiazol-3-ium-5-yl)ethanol
• 化学式: C6H12N3OS+
• 分子量: 174.25
• InChiKey: ROGYOBRSVIULKV-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Methods of Treating or Preventing Cardiac Disease Associated With a High Fat Diet
  申请人：Thomas Merlin

  公开号：US20090088461A1

  公开（公告）日：2009-04-02

  The present invention relates to a method of treating or preventing cardiac disorders, myocardial inflammation or myocardial oxidative stress associated with a high fat diet or in a patient subjected to a high fat diet using the thiazolium compounds and compositions of the invention. The present invention also relates to a method of ameliorating weight gain, myocardial AGE accumulation associated, mitochondrial superoxide production, RAGE expression or PPARα expression with a high fat diet or in a patient subjected to a high fat diet using the thiazolium compounds and compositions of the invention.

  本发明涉及一种使用该发明的噻唑类化合物和组合物治疗或预防与高脂饮食相关的心脏疾病、心肌炎症或心肌氧化应激的方法。本发明还涉及一种使用该发明的噻唑类化合物和组合物改善与高脂饮食相关的体重增加、心肌AGE积累、线粒体超氧化物产生、RAGE表达或PPARα表达的方法。
• Method and composition for rejuvenating hair, nails, tissues, cells and organs by ex-vivo or immersive treatment
  申请人：——

  公开号：US20020182165A1

  公开（公告）日：2002-12-05

  A method and composition for the treatment of hair, nail, ex-vivo organ, ex-vivo cell or ex-vivo tissue to improve the biomechanical and diffusional characteristics comprising an effective amount of a compound selected from the group consisting of compounds of the formula 1

  一种用于改善生物力学和扩散特性的头发、指甲、离体器官、离体细胞或离体组织的治疗方法和组合物，包括有效量的来自化合物公式1所述化合物组合的化合物。
• Preventing and reversing the formation of advance glycosylation endproducts
  申请人：Cerami Anthony

  公开号：US20070025926A1

  公开（公告）日：2007-02-01

  The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain useful agents are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.

  本发明涉及用于抑制和逆转非酶促交联（蛋白老化）的组合物和方法。因此，披露了包含一种能够抑制目标蛋白质的高级糖基化终产物的形成的药剂的组合物，并且通过裂解在高级糖基化终产物中存在的α-二羰基基础蛋白交联来逆转预先形成的交联。某些有用的药剂是噻唑盐。该方法包括将目标蛋白质与该组合物接触。该发明既可以在工业上应用，也可以在治疗上应用，因为可以治疗食品变质和动物蛋白质老化。还披露了一种新型的免疫测定方法，用于检测非酶促交联的逆转。
• USE OF THIAZOLIUM COMPOUNDS FOR PREVENTING AND REVERSING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS
  申请人：ALTEON Inc.

  公开号：EP0808163A2

  公开（公告）日：1997-11-26
• US5853703A
  申请人：——

  公开号：US5853703A

  公开（公告）日：1998-12-29