2-methanesulfonylamino-4,5-diphenylthiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-methanesulfonylamino-4,5-diphenylthiazole
• 英文别名: N-(4,5-diphenyl-1,3-thiazol-2-yl)methanesulfonamide
• 化学式: C₁₆H₁₄N₂O₂S₂
• 分子量: 330.431
• InChiKey: XDLMXYSENCWLQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  95.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  异丙醚 、 2-氨基-4,5-二苯基噻唑 、 甲基磺酰氯 在 吡啶 、 碳酸氢钠 作用下， 以 二氯甲烷 、 水 、 乙酸乙酯 为溶剂， 生成 2-methanesulfonylamino-4,5-diphenylthiazole
  参考文献：
  名称：

  Diphenylthiazole derivative

  摘要：

  以下是通用公式（I）表示的一种新的二苯噻唑衍生物：##STR1##其中m和n分别为1或2；R.sup.1和R.sup.2分别表示氢原子、低烷基基团、低烷氧基团、低烷基硫基团、硝基、氨基、甲磺酰氧基团或卤素原子；A.sup.1表示低烷基磺酰基、卤代低烷基磺酰基、取代苯磺酰基、低酰基或卤代低酰基；A.sup.2表示氢原子、低烷基磺酰基、卤代低烷基磺酰基或低烷基基团，并且作为一种具有抗炎、镇痛、抗过敏、利尿或抑制血小板聚集作用的药物。

  公开号：

  US05449783A1

文献信息

• NOVEL DIPHENYLTHYAZOLE DERIVATIVE
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP0592664A1

  公开（公告）日：1994-04-20

  A novel diphenylthiazole derivative which is effectively used as a medicine with an anti-inflammaory, analgesic, antiallergic, uric acid excretion stimulating, or platelet aggregation inhibiting action and is represented by general formula (I), wherein m and n are each 1 or 2; R¹ and R² each represents hydrogen, lower alkyl, lower alkoxy, lower alkylsulfonyl, nitro, amino, methanesulfonyloxy, or halogen; A¹ represents lower alkanesulfonyl, halogenated lower alkanesulfonyl, substituted bezenesulfonyl, lower acyl, or halogenated lower acyl; and A² represents hydrogen, lower alkanesulfonyl, halogenated lower alkanesulfonyl, or lower alkyl.

  一种新型二苯基噻唑衍生物，可有效用作具有抗炎、镇痛、抗过敏、促进尿酸排泄或抑制血小板聚集作用的药物，由通式(I)表示，其中m和n各为1或2；R¹ 和 R² 各自代表氢、低级烷基、低级烷氧基、低级烷磺酰基、硝基、氨基、甲磺酰氧基或卤素；A¹ 代表低级烷磺酰基、卤代低级烷磺酰基、取代的苯磺酰基、低级酰基或卤代低级酰基；A² 代表氢、低级烷磺酰基、卤代低级烷磺酰基或低级烷基。
• AGENT FOR IMPROVEMENT IN BOUNCE/BODY OF HAIR, AND HAIR COSMETIC
  申请人：Shiseido Company, Limited

  公开号：EP1911750A1

  公开（公告）日：2008-04-16

  A hair resiliency and body improver comprising as the active ingredient thereof one or more types of compounds selected from the group consisting of 2-aminothiazole derivatives represented by the following general formula (1) or 3-aminoisoxazole derivatives represented by the following general formula (2), and pharmaceutically acceptable salts thereof: (wherein, R1, R2, R3, R4, n and m are as defined in the description).

  一种头发弹性和发质改善剂，其活性成分包括一种或多种选自由下通式 (1) 所代表的 2-氨基噻唑衍生物或自由下通式 (2) 所代表的 3-氨基异恶唑衍生物组成的组的化合物及其药学上可接受的盐类： (其中，R1、R2、R3、R4、n 和 m 如说明中所定义）。
• Hair resiliency / body improver and hair cosmetic
  申请人：Shiseido Company, Limited

  公开号：EP2484342A1

  公开（公告）日：2012-08-08

  A hair resiliency and body improver comprising as the active ingredient thereof one or more types of compounds selected from the group consisting of 2-aminothiazole derivatives represented by the following general formula (1) or 3-aminoisoxazole derivatives represented by the following general formula (2), and pharmaceutically acceptable salts thereof: (wherein, R1, R2, R3, R4, n and m are as defined in the description).

  一种头发弹性和发质改善剂，其活性成分包括一种或多种选自由下通式 (1) 所代表的 2-氨基噻唑衍生物或自由下通式 (2) 所代表的 3-氨基异恶唑衍生物组成的组的化合物及其药学上可接受的盐类： (其中，R1、R2、R3、R4、n 和 m 如说明中所定义）。
• DERIVATIVES OF DIPHENYLTHIAZOLE WITH ANTIINFLAMMATORY ACTIVITY
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP0592664B1

  公开（公告）日：2000-07-05
• Hair resiliency/body improver and hair cosmetic
  申请人：Suetsugu Masaru

  公开号：US20090233975A1

  公开（公告）日：2009-09-17

  A hair resiliency and body improver comprising as the active ingredient thereof one or more types of compounds selected from the group consisting of 2-aminothiazole derivatives represented by the following general formula (1) or 3-aminoisoxazole derivatives represented by the following general formula (2), and pharmaceutically acceptable salts thereof: (wherein, R 1 , R 2 , R 3 , R 4 , n and m are as defined in the description).