(1R,2R)-2-[[4-(1,3-benzoxazol-2-yl)phenyl]methoxy]cyclohexan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (1R,2R)-2-[[4-(1,3-benzoxazol-2-yl)phenyl]methoxy]cyclohexan-1-amine
• 化学式: C₂₀H₂₂N₂O₂
• 分子量: 322.4
• InChiKey: YOWIFYHPZZADKG-SJLPKXTDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  61.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• REMEDY FOR XANTHOMA
  申请人：National University Corp. Kobe University

  公开号：EP1889632A1

  公开（公告）日：2008-02-20

  A preventive/remedy for xanthoma which contains a compound having an inhibitory effect on squalene synthase, its prodrug or its salt.

  一种黄疽的预防/治疗方法，其中含有一种对角鲨烯合成酶有抑制作用的化合物、其原药或其盐。
• EP0676960A4
  申请人：——

  公开号：EP0676960A4

  公开（公告）日：1995-11-15
• CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS
  申请人：RHONE-POULENC RORER PHARMACEUTICALS, INC.

  公开号：EP0676960A1

  公开（公告）日：1995-10-18
• Skeletal muscle protecting agent
  申请人：Tozawa Ryuichi

  公开号：US20080113965A1

  公开（公告）日：2008-05-15

  The present invention provides a novel drug which is useful as a skeletal muscle protecting agent comprising a compound having inhibitory activity against squalene synthase or a salt thereof, or a prodrug thereof.
• Crp Lowering Agent
  申请人：Imura Yoshimi

  公开号：US20090118255A1

  公开（公告）日：2009-05-07

  The present invention provides a novel drug which is useful as a preventive and/or therapeutic agent for various diseases involved in elevation of CRP level, in particular, inflammatory disease and cancer comprising a compound having inhibitory activity against squalene synthase or a salt thereof, or a prodrug thereof.