2-ethyl-1-morpholin-4-yl-pent-2-en-1-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-ethyl-1-morpholin-4-yl-pent-2-en-1-one
• 英文别名: (E)-2-ethyl-1-morpholin-4-ylpent-2-en-1-one
• 化学式: C₁₁H₁₉NO₂
• 分子量: 197.277
• InChiKey: XVLWHXSJWUIKMJ-BJMVGYQFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吗啉 、 3-己炔 、 一氧化碳 在 Pf(OAc)2 [bmim][Tf₂N] 、 1,3-双(二苯基膦)丙烷 作用下， 110.0 ℃ 、1.38 MPa 条件下， 反应 22.0h， 以26%的产率得到2-ethyl-1-morpholin-4-yl-pent-2-en-1-one
  参考文献：
  名称：

  Palladium-Catalyzed Regiospecific Aminocarbonylation of Alkynes in the Ionic Liquid [bmim][Tf₂N]

  摘要：

  Regiospecific construction of 2-substituted acrylamides was achieved by palladium-catalyzed aminocarbonylation of alkynes in the ionic liquid [bmim][Tf2N] without any acid additive under relatively mild conditions. The ionic liquid was used as the reaction medium and also acted as a promoter. Acrylamides were obtained in moderate to excellent yields, and an important feature is that the catalyst system can be recycled five times without loss of catalytic activity.

  DOI：

  10.1021/ol061675v

文献信息

• Palladium-Catalyzed Regiospecific Aminocarbonylation of Alkynes in the Ionic Liquid [bmim][Tf₂N]
  作者：Yu Li、Howard Alper、Zhengkun Yu

  DOI：10.1021/ol061675v

  日期：2006.11.9

  Regiospecific construction of 2-substituted acrylamides was achieved by palladium-catalyzed aminocarbonylation of alkynes in the ionic liquid [bmim][Tf2N] without any acid additive under relatively mild conditions. The ionic liquid was used as the reaction medium and also acted as a promoter. Acrylamides were obtained in moderate to excellent yields, and an important feature is that the catalyst system can be recycled five times without loss of catalytic activity.