1-(5-Phenyl-1,3-thiazol-2-yl)-3-(piperidin-4-ylmethyl)urea

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(5-Phenyl-1,3-thiazol-2-yl)-3-(piperidin-4-ylmethyl)urea
• 化学式: C₁₆H₂₀N₄OS
• 分子量: 316.4
• InChiKey: IUSPLEUKLXRAKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  94.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Tyrosine kinase inhibitors
  申请人：——

  公开号：US20040242637A1

  公开（公告）日：2004-12-02

  The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

  本发明涉及抑制、调节和/或调控酪氨酸激酶信号转导的化合物，含有这些化合物的组合物，以及用它们治疗酪氨酸激酶依赖性疾病和病症的方法，如哺乳动物的血管生成、癌症、肿瘤生长、动脉粥样硬化、老年性黄斑变性、糖尿病视网膜病变、炎症性疾病等。
• [EN] TYROSINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE TYROSINES KINASES
  申请人：MERCK & CO INC

  公开号：WO2003015717A2

  公开（公告）日：2003-02-27

  The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.