4-(4-acetamidopiperidin-1-yl)-9H-pyrimido[4,5-b]indole-6-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-(4-acetamidopiperidin-1-yl)-9H-pyrimido[4,5-b]indole-6-carboxamide
• 化学式: C₁₈H₂₀N₆O₂
• 分子量: 352.4
• InChiKey: ITXRUSBHZBHGFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• PYRIMIDO (4,5-B) INDOLE DERIVATIVES
  申请人：Bayer HealthCare AG

  公开号：EP1442039A1

  公开（公告）日：2004-08-04
• US9409906B2
  申请人：——

  公开号：US9409906B2

  公开（公告）日：2016-08-09
• [EN] PYRIMIDO [4,5-B] INDOLE DERIVATIVES<br/>[FR] DERIVES DE PYRIMIDO [4,5-B] INDOLE
  申请人：BAYER AG

  公开号：WO2003037898A1

  公开（公告）日：2003-05-08

  The present invention relates to pyrimido[4,5-b]indoles which are useful as an active ingredient of pharmaceutical preparations. The pyrimido[4,5-b]indoles of the present invention have MKK7 and MKK4 inhibitory activity, and can be used for the prophylaxis and treatment of diseases associated with MKK7 and MKK4 activity. Such diseases include, inflammatory and immunoregulatory disorders and diseases such as asthma, atopic dermatitis, rhinitis, allergic rhinitis, allergic diseases, COPD, septic shock, arthritis, joint diseases and myocardial injuries, as well as autoimmune pathologies such as rheumatoid arthritis, Grave's disease, and atherosclerosis. The compounds of the present invention are also useful for treatment of ischemia, myocardial injury, pulmonary hypertension, renal failure, Huntington's chorea and cardiac hypertrophy, as well as neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and focal ischemia.