7-[(3-benzylpiperidin-1-yl)carbonyl]-1,6-naphthyridin-8-ol | 442911-08-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 7-[(3-benzylpiperidin-1-yl)carbonyl]-1,6-naphthyridin-8-ol
• 英文别名: (3-Benzylpiperidin-1-yl)-(8-hydroxy-1,6-naphthyridin-7-yl)methanone
• CAS: 442911-08-2
• 化学式: C₂₁H₂₁N₃O₂
• 分子量: 347.417
• InChiKey: FYBGYUXMXRJOED-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  66.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Aza-and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
  申请人：——

  公开号：US20040044207A1

  公开（公告）日：2004-03-04

  Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating, or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

  本文描述了包括某些喹啉羧酰胺和萘啶羧酰胺衍生物在内的Aza-和polyaza-萘基羧酰胺衍生物，作为HIV整合酶的抑制剂和HIV复制的抑制剂。这些化合物可作为化合物或药物可接受的盐，或作为药物组成部分，可选与其他抗病毒药物、免疫调节剂、抗生素或疫苗组合使用，用于预防或治疗HIV感染和治疗艾滋病。还描述了预防、治疗或延迟艾滋病发作的方法以及预防或治疗HIV感染的方法。
• AZA-AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS
  申请人：Merck & Co., Inc.

  公开号：EP1326610B1

  公开（公告）日：2006-11-15
• EP1326610A4
  申请人：——

  公开号：EP1326610A4

  公开（公告）日：2004-06-09
• US6841558B2
  申请人：——

  公开号：US6841558B2

  公开（公告）日：2005-01-11
• [EN] AZA-AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS<br/>[FR] AZA- ET POLYAZA-NAPHTHALENYL CARBOXAMIDES CONVENANT COMME INHIBITEURS DE L'INTEGRASE DU VIH
  申请人：MERCK & CO INC

  公开号：WO2002055079A2

  公开（公告）日：2002-07-18

  Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating, or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.