2-chloro-5-methoxy-4-[5-[[(2S)-piperidin-1-ium-2-yl]methyl]-1,2,4-oxadiazol-3-yl]aniline;chloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-chloro-5-methoxy-4-[5-[[(2S)-piperidin-1-ium-2-yl]methyl]-1,2,4-oxadiazol-3-yl]aniline;chloride
• 化学式: C15H20Cl2N4O2
• 分子量: 359.2
• InChiKey: REJAZUNAPHVYQR-FVGYRXGTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.09
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  86.2
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• COMBINATION OF ACETYLCHOLINESTERASE INHIBITOR AND 5-HT4 RECEPTOR AGONIST AS NEUROPROTECTIVE AGENT IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：Université de Caen Normandie

  公开号：EP3628315A1

  公开（公告）日：2020-04-01

  The present invention concerns a pharmaceutical composition comprising an acetylcholinesterase inhibitor and a 5-HT4 receptor agonist, for use as neuroprotective agent in the prevention and/or treatment of a neurodegenerative disease. It also concerns a neuroprotective pharmaceutical combination comprising an acetylcholinesterase inhibitor and a 5-HT4 receptor agonist for simultaneous, separate or sequential use as neuroprotective agent in the prevention and/or treatment of a neurodegenerative disease.

  本发明涉及一种由乙酰胆碱酯酶抑制剂和 5-HT4 受体激动剂组成的药物组合物，可作为神经保护剂用于预防和/或治疗神经退行性疾病。本发明还涉及一种由乙酰胆碱酯酶抑制剂和 5-HT4 受体激动剂组成的神经保护药物组合物，可同时、单独或连续用作神经保护剂，预防和/或治疗神经退行性疾病。
• Combination of Acetylcholinesterase Inhibitor and 5-HT4 Receptor Agonist As Neuroprotective Agent In the Treatment of Neurodegenerative Diseases
  申请人：UNIVERSITE DE CAEN NORMANDIE

  公开号：US20210338647A1

  公开（公告）日：2021-11-04

  A pharmaceutical composition including an acetylcholinesterase inhibitor and a 5-HT 4 receptor agonist, for use as neuroprotective agent in the prevention and/or treatment of a neurodegenerative disease; and a neuroprotective pharmaceutical combination including an acetylcholinesterase inhibitor and a 5-HT 4 receptor agonist for simultaneous, separate or sequential use as neuroprotective agent in the prevention and/or treatment of a neurodegenerative disease.