N-acetyl-4-[2-(4-ethoxy-phenyl)-6-trifluoromethyl-pyrazolo[1,5-a]pyridin-3-yl]-benzenesulfonamide | 267235-65-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-acetyl-4-[2-(4-ethoxy-phenyl)-6-trifluoromethyl-pyrazolo[1,5-a]pyridin-3-yl]-benzenesulfonamide
• 英文别名: N-[4-[2-(4-ethoxyphenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]phenyl]sulfonylacetamide
• CAS: 267235-65-4
• 化学式: C₂₄H₂₀F₃N₃O₄S
• 分子量: 503.502
• InChiKey: LPXTVBIJCVTUJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  98.2
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• PYRAZOLOPYRIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1127058B1

  公开（公告）日：2004-09-01
• US7223772B1
  申请人：——

  公开号：US7223772B1

  公开（公告）日：2007-05-29
• [EN] PYRAZOLOPYRIDINE DERIVATIVES AS SELECTIVE COX-2 INHIBITORS<br/>[FR] DERIVES DE PYRAZOLOPYRIDINE UTILISES COMME INHIBITEURS SELECTIFS DE COX-2
  申请人：GLAXO GROUP LTD

  公开号：WO2000026216A1

  公开（公告）日：2000-05-11

  The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which : R?0 and R1¿ are independently selected from H, halogen, C¿1-6?alkyl, C1-6alkoxy, or C1-6alkoxy substituted by one or more fluorine atoms; R?2¿ is H, C¿1-6?alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms; and R?3¿ is C¿1-6?alkyl or NH2. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.