3-(3,5-dichloro-2-hydroxyphenyl)-3-[[2-[[3-hydroxy-5-[[(5S)-5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl]amino]benzoyl]amino]acetyl]amino]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 3-(3,5-dichloro-2-hydroxyphenyl)-3-[[2-[[3-hydroxy-5-[[(5S)-5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl]amino]benzoyl]amino]acetyl]amino]propanoic acid
• 化学式: C₂₂H₂₃Cl₂N₅O₇
• 分子量: 540.3
• InChiKey: ZABQRLFKWHUGJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  193
• 氢给体数：
  8
• 氢受体数：
  8

文献信息

• [EN] THE R-ISOMER OF BETA AMINO ACID COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES<br/>[FR] ISOMERE R DE COMPOSES D'ACIDES AMINES BETA EN TANT QUE DERIVES ANTAGONISTES DU RECEPTEUR DES INTEGRINES
  申请人：PHARMACIA CORPRATION

  公开号：WO2004060376A1

  公开（公告）日：2004-07-22

  The present invention relates to a class of compounds represented by the Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the αVβ3 and/or the αV β5 integrin without significantly inhibiting the αV β6 integrin

  本发明涉及一类由公式(I)表示的化合物或其药用可接受的盐，包含公式(I)化合物的药物组合物，以及在不显著抑制αVβ6整合素的情况下选择性抑制或拮抗αVβ3和/或αVβ5整合素的方法。
• [EN] META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS<br/>[FR] DÉRIVÉS D'ACIDE AMINOBENZOÏQUE MÉTA-AZACYCLIQUE À TITRE D'ANTAGONISTES DE PAN-INTÉGRINE
  申请人：UNIV SAINT LOUIS

  公开号：WO2017117538A1

  公开（公告）日：2017-07-06

  The present disclosure provides pharmaceutical agents of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.

  本公开提供了以下公式的药物代理：其中变量在此处定义。还提供了包含这种药物代理的药物组合物、工具包和制造品。还提供了使用这种药物代理治疗各种疾病和疾病的方法。
• [EN] META-AZACYCLIC AMINO BENZOIC ACID COMPOUNDS AND DERIVATIVES THEREOF BEING INTEGRIN ANTAGONISTS<br/>[FR] COMPOSES D'ACIDE META-AZACYCLIQUE AMINO BENZOIQUE ET DERIVES ANTAGONISTES DE L'INTEGRINE
  申请人：G.D. SEARLE & CO.

  公开号：WO1999044994A1

  公开（公告）日：1999-09-10

  (EN) The present invention is directed to compounds of formula (1) and pharmaceutically acceptable salts and isomers thereof useful as $g(a)v$g(b)3 integrin antagonists.(FR) L'invention concerne des composés représentés par la formule (1) ainsi que des sels pharmaceutiquement acceptables et des isomères de ces composés convenant comme antagonistes de la $g(a)v$g(b)3.

  (中文) 本发明涉及式(1)的化合物及其药学上可接受的盐和异构体，用作$g(a)v$g(b)3整合素拮抗剂。
• Alpha v beta 3 integrin antagonists in combination with chemotherapeutic agents
  申请人：——

  公开号：US20030050250A1

  公开（公告）日：2003-03-13

  The present invention is directed to compounds of the formula 1 and pharmaceutically acceptable salts and isomers thereof administered in combination with chemotherapeutic agents.

  本发明涉及公式1化合物及其药物可接受的盐和异构体，其与化学治疗药物联合给药。
• R-isomer of beta amino acid compounds as integrin receptor antagonists derivatives
  申请人：Rogers Thomas

  公开号：US20050020505A1

  公开（公告）日：2005-01-27

  The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the α v β 3 and/or the α v β 5 integrin without significantly inhibiting the α v β 6 integrin.

  本发明涉及一类由公式I表示的化合物或其药学上可接受的盐，包括公式I化合物的制药组合物，以及选择性抑制或拮抗αvβ3和/或αvβ5整合素而不显著抑制αvβ6整合素的方法。