Ac-YVAD-CMK

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: Ac-YVAD-CMK
• 英文别名: (3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-5-chloro-4-oxopentanoic acid
• 化学式: C₂₄H₃₃ClN₄O₈
• 分子量: 541.0
• InChiKey: UOUBHJRCKHLGFB-DGJUNBOTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  37
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  191
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• PROTECTION OF CELLS FROM ALU-RNA-INDUCED DEGENERATION AND INHIBITORS FOR PROTECTING CELLS
  申请人：University Of Kentucky Research Foundation

  公开号：EP3366302A1

  公开（公告）日：2018-08-29

  A method of protecting a cell includes inhibiting an inflammasome, MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NPκB of the cell. Administering an inhibitor of MyD88, IL-18, VDAC1, VDAC2, caspase-8, and/or NPκB can protect the cell from Alu-RNA-induced degeneration. Protecting a cell, such as an retinal pigment epithelium (RPE), can be therapeutically useful in the context of age-related macular degeneration and geographic atrophy.

  一种保护细胞的方法包括抑制细胞的炎性体、MyD88、IL-18、VDAC1、VDAC2、caspase-8和/或NPκB。施用MyD88、IL-18、VDAC1、VDAC2、caspase-8和/或NPκB的抑制剂可保护细胞免受Alu-RNA诱导的变性。保护视网膜色素上皮细胞（RPE）等细胞对老年性黄斑变性和地理萎缩有治疗作用。
• PROTECTION OF CELLS FROM ALU-RNA-INDUCED DEGENEREATION AND INHIBITORS FOR PROTECTING CELLS
  申请人：University Of Kentucky Research Foundation

  公开号：EP2734240B1

  公开（公告）日：2018-03-21
• Compositions and Methods for Inhibiting Stem Cell Aging
  申请人：The Regents of the University of California

  公开号：US20190185820A1

  公开（公告）日：2019-06-20

  The present disclosure provides methods of improving the function of stem cells, and/or reducing or inhibiting or inhibiting stem cell aging.
• CLOSED-ENDED DNA (CEDNA) AND USE IN METHODS OF REDUCING GENE OR NUCLEIC ACID THERAPY RELATED IMMUNE RESPONSE
  申请人：Generation Bio Co.

  公开号：US20220119840A1

  公开（公告）日：2022-04-21

  Provided herein are methods and constructs related to minimizing immune responses using inhibitors of the immune response, in particular the innate immune response, when administering a desired transgene in a cell achieved by delivery of the transgene with repeated doses of a ceDNA vector.
• US9453226B2
  申请人：——

  公开号：US9453226B2

  公开（公告）日：2016-09-27