2-Bromo-4-ethyl-5-methyl-1,3-thiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Bromo-4-ethyl-5-methyl-1,3-thiazole
• 化学式: C₆H₈BrNS
• 分子量: 206.11
• InChiKey: MALUCMLGBXIPGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• N-alkylated thiazolium salts and process for their preparation
  申请人：——

  公开号：US20040019219A1

  公开（公告）日：2004-01-29

  The present invention relates to N-alkylated thiazolium salts, to a process for their preparation and also to their use as condensation and dehydrating agents.

  本发明涉及N-烷基化噻唑盐的制备方法以及它们作为缩合和脱水剂的用途。
• Diamine Derivatives
  申请人：Ohta Toshiharu

  公开号：US20110312990A1

  公开（公告）日：2011-12-22

  A compound represented by the general formula (1): -Q 1 -Q 2 -T 0 -N(R 1 )-Q 3 -N(R 2 )-T 1 -Q 4 (1) wherein R 1 and R 2 are hydrogen atoms or the like; Q 1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q 2 is a single bond or the like; Q 3 is a group in which Q 5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T 0 and T 1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

  化合物的一般式表示为(1)：-Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4(1)，其中R1和R2为氢原子或类似物；Q1为饱和或不饱和的5-或6-成员环烃基，可以是取代基或类似物；Q2为单键或类似物；Q3为其中Q5为1至8个碳原子的烷基或类似物的基团；T0和T1为羰基或类似物。该化合物及其盐、溶剂化物或N-氧化物可用于预防和/或治疗脑梗死、脑栓塞、心肌梗死、心绞痛、肺梗死、肺栓塞、布尔格病、深静脉血栓形成、弥散性血管内凝血综合征、瓣膜或关节置换后的血栓形成、血管成形术后的血栓形成和再闭塞、全身性炎症反应综合征(SIRS)、多器官功能障碍综合征(MODS)、体外循环期间的血栓形成或采血时的血液凝固。
• N-alkylierte Thiazoliumsalze und Verfahren zu deren Herstellung
  申请人：BAYER AG

  公开号：EP1371651A2

  公开（公告）日：2003-12-17

  Die vorliegende Erfindung betrifft N-alkylierte Thiazoliumsalze, ein Verfahren zu ihrer Herstellung sowie die Verwendung als Kondensations- und Dehydratisierungsmittel.

  本发明涉及 N-烷基化噻唑盐、其制备工艺及其作为冷凝剂和脱水剂的用途。
• BENZOTHIAZOLE AND BENZOTHIOPHENE COMPOUNDS
  申请人：Bristol-Myers Squibb Company

  公开号：US20180036287A1

  公开（公告）日：2018-02-08

  The present invention provides benzothiazole compounds or benzothiophene compounds of Formula I having the structure: wherein X 1 , X 2 , X 3 , X 4 , X 5 , Y, WR 2 , R 3 , R 4 , R 5 , R 6 , R 7 and AA and other moieties are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.