2-methoxy-5-(7H-purin-8-yl)aniline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-methoxy-5-(7H-purin-8-yl)aniline
• 化学式: C₁₂H₁₁N₅O
• 分子量: 241.25
• InChiKey: PHCIHXNQKVXASE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  89.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• 6,5-Fused bicyclic heterocycles
  申请人：——

  公开号：US20040014759A1

  公开（公告）日：2004-01-22

  The present invention provides compounds of Formula (I) wherein Q 1 , Q 2 , Q 3 , Q 4 , Y 1 , Y 2 , and Z are as defined in the description, and pharmaceutically acceptable salts thereof, and C 1 -C 8 alkyl esters thereof, which are useful for the treatment of diseases responsive to the inhibition of the enzyme 15-lipoxygenase. Thus, the compounds of Formula (I) and their pharmaceuticalyl acceptable salts are useful for treating diseases with an inflammatory component, including atherosclerosis, diseases involving chemotaxis of monocytes, inflammation, stroke, coronary artery disease, asthma, arthritis, colorectal cancer, and psoriasis. 1

  本发明提供了Formula (I)中的化合物，其中Q1、Q2、Q3、Q4、Y1、Y2和Z如描述中定义，并且其药用盐和C1-C8烷基酯，这些化合物对于治疗对15-脂氧合酶抑制有响应的疾病是有用的。因此，Formula (I)中的化合物及其药用盐对于治疗具有炎症成分的疾病是有用的，包括动脉粥样硬化、涉及单核细胞趋化、炎症、中风、冠状动脉疾病、哮喘、关节炎、结直肠癌和银屑病。
• 6,5-FUSED BICYCLIC HETEROCYCLES
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1294718A2

  公开（公告）日：2003-03-26
• US6943174B2
  申请人：——

  公开号：US6943174B2

  公开（公告）日：2005-09-13
• [EN] 6,5-FUSED BICYCLIC HETEROCYCLES<br/>[FR] HETEROCYLES BICYCLIQUES FONDUS -6,5
  申请人：WARNER LAMBERT CO

  公开号：WO2001096336A2

  公开（公告）日：2001-12-20

  The present invention provides compounds of Formula (I) wherein Q1, Q2, Q3, Q4, Y1, Y2, and Z are as defined in the description, and pharmaceutically acceptable salts thereof, and C1-C8 alkyl esters thereof, which are useful for the treatment of diseases responsive to the inhibition of the enzyme 15-lipoxygenase. Thus, the compounds of Formula (I) and their pharmaceuticalyl acceptable salts are useful for treating diseases with an inflammatory component, including atherosclerosis, diseases involving chemotaxis of monocytes, inflammation, stroke, coronary artery disease, asthma, arthritis, colorectal cancer, and psoriasis.