1-(2-chloro-5-thiazolyl)methyl-1,4,5,6-tetrahydropyrimidine | 371122-91-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2-chloro-5-thiazolyl)methyl-1,4,5,6-tetrahydropyrimidine
• 英文别名: 2-chloro-5-(5,6-dihydro-4H-pyrimidin-1-ylmethyl)-1,3-thiazole
• CAS: 371122-91-7
• 化学式: C₈H₁₀ClN₃S
• 分子量: 215.706
• InChiKey: HIRRRHOGLOOSHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  56.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Cyclic amidine compounds
  申请人：——

  公开号：US20030100769A1

  公开（公告）日：2003-05-29

  There is provided cyclic amidine compounds of the following formula (I): 1 wherein: A 1 and A 2 are hydrogen atom, optionally substituted alkyl group; optionally substituted aryl group; or optionally substituted heterocyclic group; and X is —C(R 1 ,R 2 )—C(R 3 ,R 4 )—, —C(R 5 )═C(R 6 )—, —C(R 7 ,R 8 )—C(R 9 ,R 10 )—C(R 11 ,R 12 )—, or —C(R 13 ,R 14 )—C(R 15 ,R 16 )—NH— (wherein, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , R 15 and R 16 are hydrogen atom; halogen atom; optionally substituted alkyl group; optionally substituted aryl group; or optionally substituted heterocyclic group; or pharmaceutically acceptable salts thereof. These compounds have good affinity for &agr;4&bgr;2 nicotinic acetylcholine receptors and activate the same to thereby exert a preventive or therapeutic effect on cerebral dysfunction.

  提供了以下式子（I）的环状腙类化合物：1其中：A1和A2为氢原子，可选取代烷基，可选取代芳基或可选取代杂环基；X为—C（R1，R2）—C（R3，R4）—，—C（R5）═C（R6）—，—C（R7，R8）—C（R9，R10）—C（R11，R12）—或—C（R13，R14）—C（R15，R16）—NH—（其中，R1、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12、R13、R14、R15和R16为氢原子，卤素原子，可选取代烷基，可选取代芳基或可选取代杂环基）或其药学上可接受的盐。这些化合物对α4β2型尼古丁乙酰胆碱受体具有良好的亲和力，并激活该受体，从而对脑功能障碍产生预防或治疗作用。
• CYCLIC AMIDINE COMPOUNDS AND THEIR USE AS ALPHA4BETA2 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
  申请人：SUNTORY LIMITED

  公开号：EP1280793A2

  公开（公告）日：2003-02-05
• [EN] CYCLIC AMIDINE COMPOUNDS<br/>[FR] COMPOSES AMIDINES CYCLIQUES
  申请人：SUNTORY LTD

  公开号：WO2001081334A2

  公开（公告）日：2001-11-01

  There is provided cyclic amidine compounds of the following formula (I) wherein: A?1 and A2¿ are hydrogen atom, optionally substituted alkyl group; optionally substituted aryl group; or optionally substituted heterocyclic group; and X is -C(R?1,R2)-C(R3,R4¿)-, -C(R5)=C(R6)-, -C(R?7,R8)-C(R9,R10)-C(R11,R12¿)-, or -C(R?13,R14)-C(R15,R16¿)-NH- (wherein, R?1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11R12, R13, R14, R15 and R16¿ are hydrogen atom; halogen atom; optionally substituted alkyl group; optionally substituted aryl group; or optionally substituted heterocyclic group;or pharmaceutically acceptable salts thereof. These compounds have good affinity for α4β2 nicotinic acetylcholine receptors and activate the same to thereby exert a preventive or therapeutic effect on cerebral dysfunction.