(S,S)-1,2-bis(1-hydroxy-2-methylpropyl)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S,S)-1,2-bis(1-hydroxy-2-methylpropyl)benzene
• 英文别名: (S)-1-[2-((S)-1-hydroxy-2-methylpropyl)-phenyl]-2-methyl-propan-1-ol；(S)-1-[2-((S)-1-Hydroxy-2-methylpropyl)phenyl]-2-methyl-propan-1-ol；(1S)-1-[2-[(1S)-1-hydroxy-2-methylpropyl]phenyl]-2-methylpropan-1-ol
• 化学式: C₁₄H₂₂O₂
• 分子量: 222.327
• InChiKey: SJXONIXDOLDYPY-KBPBESRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苯膦酰二氯 、 (S,S)-1,2-bis(1-hydroxy-2-methylpropyl)benzene 在 吡啶 作用下， 反应 1.5h， 以89%的产率得到(1S,5S)-1,5-diisopropyl-3-phenyl-1,5-dihydro-benzo[e][1,3,2]dioxa-phosphepine-3-oxide
  参考文献：
  名称：

  [EN] CHIRAL DIOLS, THEIR MANUFACTURE AND LIGANDS AND CATALYSTS DERIVED THEREFROM
  [FR] NOUVEAUX DIOLS CHIRAUX, FABRICATION, LIGANDS ET CATALYSEURS DERIVES DE CES DIOLS

  摘要：

  公开号：

  WO2004031109A3
• 作为产物：
  描述：

  1,2-bis((S)-1-(((3aS,6aS)-3a-allylhexahydro-6aH-cyclopenta[b]furan-6a-yl)oxy)-2-methylpropyl)benzene 在 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以87%的产率得到(S,S)-1,2-bis(1-hydroxy-2-methylpropyl)benzene
  参考文献：
  名称：

  手性拆分剂 (S)-ALBO-V 光学拆分具有邻二甲苯结构的 C2-对称外消旋 1,4-二醇

  摘要：

  使用 (S)-5-allyl-2-oxabicyclo[3.3.0] 辛烯 ((S)- ALBO-V) 作为手性拆分剂。非对映体...

  DOI：

  10.1246/bcsj.20150066

文献信息

• Chiral diols, their manufacture and ligands and catalysts derived therefrom
  申请人：Berens Ulrich

  公开号：US20060030737A1

  公开（公告）日：2006-02-09

  The present invention relates to a method for the preparation of C 2 -symmetric 1,4-diols of the formula IVA or IVB, wherein ring A, R 1 and R 2 have the meanings given in the specification, that makes use of the metallation of pure enantiomers of α-(aryl or heteroaryl)-α-substituted alkanol compounds or the use of said alkanol compounds in the preparation of said mmetric 1,4-diols; novel C 2 -symmetric 1,4-diols in enantiomerically pure form; and methods of use or their use in the synthesis of chiral ligands which find use to produce catalysts for a variety of asymmetric transformations such as hydrogenations.

  本发明涉及一种制备式IVA或IVB的C2对称1,4-二醇的方法，其中环A、R1和R2具有规范中给出的含义，利用纯对映体α-(芳基或杂环芳基)-α-取代烷醇化合物的金属化或利用该烷醇化合物制备所述对称1,4-二醇；新颖的对映纯形式的C2对称1,4-二醇；以及它们在合成手性配体中的应用或用于制备各种不对称转化的催化剂，例如氢化反应。
• CHIRAL DIOLS, THEIR MANUFACTURE AND LIGANDS AND CATALYSTS DERIVED THEREFROM
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1546077A2

  公开（公告）日：2005-06-29
• US7465838B2
  申请人：——

  公开号：US7465838B2

  公开（公告）日：2008-12-16
• [EN] NEW CHIRAL DIOLS, THEIR MANUFACTURE AND LIGANDS AND CATALYSTS DERIVED THEREFROM<br/>[FR] NOUVEAUX DIOLS CHIRAUX, FABRICATION, LIGANDS ET CATALYSEURS DERIVES DE CES DIOLS
  申请人：CIBA SC HOLDING AG

  公开号：WO2004031109A2

  公开（公告）日：2004-04-15

  The present invention relates to a method for the preparation of C2-symmetric 1,4-diols of the formula IVA or IVB, wherein ring A, R1 and R2 have the meanings given in the specification, that makes use of the metallation of pure enantiomers of α-(aryl or heteroaryl)-α-substituted alkanol compounds or the use of said alkanol compounds in the preparation of said mmetric 1,4-diols; novel C2­-symmetric 1,4-diols in enantiomerically pure form; and methods of use or their use in the synthesis of chiral ligands which find use to produce catalysts for a variety of asymmetric transformations such as hydrogenations.
• [EN] CHIRAL DIOLS, THEIR MANUFACTURE AND LIGANDS AND CATALYSTS DERIVED THEREFROM<br/>[FR] NOUVEAUX DIOLS CHIRAUX, FABRICATION, LIGANDS ET CATALYSEURS DERIVES DE CES DIOLS
  申请人：CIBA SC HOLDING AG

  公开号：WO2004031109A3

  公开（公告）日：2004-12-23