N-[2-[di(propan-2-yl)amino]ethyl]-5-[(Z)-[4-(3-methoxyphenyl)-2-oxo-1H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-[2-[di(propan-2-yl)amino]ethyl]-5-[(Z)-[4-(3-methoxyphenyl)-2-oxo-1H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
• 化学式: C₃₁H₃₈N₄O₃
• 分子量: 514.7
• InChiKey: WWGVQMBGZSNBOQ-UQQQWYQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  86.5
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• 4-(HETERO)ARYL SUBSTITUTED INDOLINONES
  申请人：Sugen, Inc.

  公开号：EP1349852A2

  公开（公告）日：2003-10-08
• [EN] 4-ARYL SUBSTITUTED INDOLINONES<br/>[FR] INDOLINONES 4-ARYL SUBSTITUEES
  申请人：CUI JINGRONG

  公开号：WO2002055517A2

  公开（公告）日：2002-07-18

  The present invention relates to 4-arylindolinones of formula (I), as well as pharmaceutical compositions thereof, capable of modulating protein kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation. The present invention relates to methods for treating protein kinase related disorders. Formula (I) wherein: R1 is an optionally substituted aryl or heteroaryl substituent, R2-R5 are as in claim 1.