[3H]azietomidate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [3H]azietomidate
• 英文别名: 2-(3-methyldiazirin-3-yl)ethyl 3-(1-phenylethyl)imidazole-4-carboxylate
• 化学式: C₁₆H₁₈N₄O₂
• 分子量: 298.34
• InChiKey: DUOHNSBKYJHAMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  68.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• ETOMIDATE ANALOGUES THAT DO NOT INHIBIT ADRENOCORTICAL STEROID SYNTHESIS
  申请人：The General Hospital Corporation

  公开号：EP2451779A2

  公开（公告）日：2012-05-16
• US8765973B2
  申请人：——

  公开号：US8765973B2

  公开（公告）日：2014-07-01
• US9187421B2
  申请人：——

  公开号：US9187421B2

  公开（公告）日：2015-11-17
• [EN] ETOMIDATE ANALOGUES THAT DO NOT INHIBIT ADRENOCORTICAL STEROID SYNTHESIS<br/>[FR] ANALOGUES DE L'ÉTOMIDATE QUI N'INHIBENT PAS LA SYNTHÈSE DE STÉROÏDES CORTICOSURRÉNAUX
  申请人：GEN HOSPITAL CORP

  公开号：WO2011005969A2

  公开（公告）日：2011-01-13

  The invention is directed to compounds according to formula (I): where R1 is L1C(O)OT or L1C(O)OL2C(O)OT; R2 is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, or R1; n is an integer from 0 to 5; each R3 is independently halogen or R2; R4 and R5 are independently H, halogen, CN or CF3; L1 and L2 are each independently a bond, a substituted or unsubstituted C1-C10 alkylene, C2-C10 alkenylene, or C2-C10 alkynylene; and T is H, a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, or C2-C10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition.