3-[2-(Cyclopropylmethoxy)-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]propanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[2-(Cyclopropylmethoxy)-4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]phenyl]propanoic acid
• 化学式: C₂₅H₂₇NO₅
• 分子量: 421.5
• InChiKey: IAIOXTLMBBJCGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  81.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Antidiabetic agents
  申请人：——

  公开号：US20030225083A1

  公开（公告）日：2003-12-04

  Compounds of formula I: 1 wherein X, E, and R′ have any of the values defined in the specification, and their pharmaceutically acceptable salts, lower blood glucose levels and are useful for treating diseases in mammals such as Non-Insulin Dependent Diabetes Mellitus. Also disclosed are pharmaceutical compositions, processes for preparing compounds of formula (I) and intermediates useful for preparing compounds of formula I.

  式子I的化合物：其中X，E和R′具有规范中定义的任何值，以及它们的药学上可接受的盐，可以降低血糖水平，并用于治疗哺乳动物的疾病，如非胰岛素依赖性糖尿病。还披露了制备式(I)化合物的制药组合物，制备式I化合物的中间体和有用的制备式I化合物的过程。
• ANTIDIABETIC AGENTS
  申请人：Warner-Lambert Company LLC

  公开号：EP1492528A1

  公开（公告）日：2005-01-05
• US6716842B2
  申请人：——

  公开号：US6716842B2

  公开（公告）日：2004-04-06
• [EN] ANTIDIABETIC AGENTS<br/>[FR] AGENTS ANTI-DIABETIQUES
  申请人：WARNER LAMBERT CO

  公开号：WO2003084535A1

  公开（公告）日：2003-10-16

  Compounds of formula (I): X, E, and R' have any of the values defined in the specification, and their pharmaceutically acceptable salts, lower blood glucose levels and are useful for treating diseases in mammals such as Non-Inuslin Dependent Diabetes Mellitus. Also disclosed are pharmaceutical compositions, process for preparing compounds of formula (I) and intermediates useful for preparing compounds of formula (I).