4-[5-[4-(3-Azidopropyl)phenyl]-3-(trifluoromethyl)pyrazol-1-yl]benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[5-[4-(3-Azidopropyl)phenyl]-3-(trifluoromethyl)pyrazol-1-yl]benzamide
• 化学式: C20H17F3N6O
• 分子量: 414.4
• InChiKey: JLHBCFRPNMLNJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  75.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Compounds and methods for inducing apoptosis in proliferating cells
  申请人：——

  公开号：US20030236294A1

  公开（公告）日：2003-12-25

  Compounds useful for inducing apoptosis in proliferative cells, particularly cancer cells, including but not limited to prostate cancer, leukemia, non-smalll cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, bladder cancer, lymphoma, and breast cancer. These compounds are particularly useful in the treatment of androgen-independent cancers, including hormone-refractory prostate cancer. Further provided are methods of treating cancer in a subject in need of such treatment using the compounds of the present invention. Further provided are methods for using the compounds of the present invention to treat, inhibit, or delay the onset of cancer in a subject. Further provided are methods of inducing apoptosis in rapidly proliferating cells, particularly, though not necessarily cancer cells, using the compounds of the present invention.

  用于诱导增殖细胞凋亡的化合物，特别是癌细胞，包括但不限于前列腺癌、白血病、非小细胞肺癌、结肠癌、中枢神经系统癌、黑色素瘤、卵巢癌、肾癌、膀胱癌、淋巴瘤和乳腺癌。这些化合物在治疗雄激素非依赖性癌症特别有效，包括激素难治性前列腺癌。还提供了使用本发明化合物治疗患有癌症的受试者的方法。此外，还提供了使用本发明化合物治疗、抑制或延迟受试者癌症发生的方法。此外，还提供了使用本发明化合物诱导快速增殖细胞凋亡的方法，特别是虽然不一定是癌细胞。
• Unsymmetrical methine and polymethine dye-molecules for fluorescent intracellular applications
  申请人：——

  公开号：US20040047806A1

  公开（公告）日：2004-03-11

  A new class of alpha-cyanomethine and alpha-cyanopolymethine dyes is provided having moieties which serve for the covalent attachment to biological substrates and resulting in the fluorescent labeling of the substrates. The labeled substrates are useful in analytical techniques for the detection and measurement of biological and clinical compounds of interest. Of particular interest is a class of methine molecules which are non-fluorescent in buffer solutions but intensely fluoresce when they enter a cell.

  提供了一种新型的α-氰基甲烷和α-氰基聚甲烷染料，其中基团用于与生物底物的共价连接，并导致底物的荧光标记。标记的底物在检测和测量感兴趣的生物和临床化合物的分析技术中非常有用。特别有趣的是一类甲烷分子，在缓冲溶液中不发荧光，但进入细胞后会强烈发荧光。
• Alpha cyano methine and polymethine dyes for the labeling of biological subtrates
  申请人：——

  公开号：US20020078857A1

  公开（公告）日：2002-06-27

  A new class of alpha-cyanomethine and alpha-cyanopolymethine dyes is provided having moieties which serve for the covalent attachment to biological substrates and resulting in the fluorescent labeling of the substrates. The labeled substrates are useful in analytical techniques for the detection and measurement of biological and clinical compounds of interest.

  提供了一种新的α-氰基甲烯和α-氰基聚甲烯染料类，具有可用于与生物底物共价连接的基团，并导致底物的荧光标记。标记的底物可用于检测和测量生物和临床感兴趣的化合物的分析技术中。
• COMPOUNDS AND METHODS FOR INDUCING APOPTOSIS IN PROLIFERATING CELLS
  申请人：THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION

  公开号：EP1499597A2

  公开（公告）日：2005-01-26
• EP1499597A4
  申请人：——

  公开号：EP1499597A4

  公开（公告）日：2006-01-25