2-[(1S)-5-[3-[4-(4,5,6,7-tetrahydro-1,3-benzoxazol-2-yl)phenoxy]propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[(1S)-5-[3-[4-(4,5,6,7-tetrahydro-1,3-benzoxazol-2-yl)phenoxy]propoxy]-2,3-dihydro-1H-inden-1-yl]acetic acid
• 化学式: C₂₇H₂₉NO₅
• 分子量: 447.5
• InChiKey: ZZKJSMBFWZMRRS-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  81.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
  申请人：Cantin Louis-David

  公开号：US20060084680A1

  公开（公告）日：2006-04-20

  This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

  本发明涉及一种新型的茚三酸衍生物，其可用于治疗糖尿病、肥胖症、高脂血症和动脉粥样硬化等疾病。本发明还涉及用于制备茚三酸衍生物的中间体以及制备方法。
• INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION
  申请人：Bayer Pharmaceuticals Corporation

  公开号：EP1578715A2

  公开（公告）日：2005-09-28
• US7714004B2
  申请人：——

  公开号：US7714004B2

  公开（公告）日：2010-05-11
• [EN] INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION<br/>[FR] DERIVES D'ACIDE ACETIQUE D'INDANE ET LEUR UTILISATION EN TANT QU'AGENTS PHARMACEUTIQUES ET INTERMEDIAIRES, ET PROCEDE DE PREPARATION CORRESPONDANT
  申请人：BAYER PHARMACEUTICALS CORP

  公开号：WO2004058174A2

  公开（公告）日：2004-07-15

  This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation, Formula (I).