[1-[2-cyanoethyl(2-methylpropyl)amino]-3-propan-2-yloxypropan-2-yl] N-[[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]methyl]carbamate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [1-[2-cyanoethyl(2-methylpropyl)amino]-3-propan-2-yloxypropan-2-yl] N-[[3-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamoylamino]phenyl]methyl]carbamate
• 化学式: C₃₂H₄₂N₆O₆
• 分子量: 606.7
• InChiKey: VOQPTKJNRLSRHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  44
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  151
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Inhibitors of IMPDH enzyme
  申请人：Stamos Dean

  公开号：US20090030051A1

  公开（公告）日：2009-01-29

  The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
• US7432290B2
  申请人：——

  公开号：US7432290B2

  公开（公告）日：2008-10-07
• US7915255B2
  申请人：——

  公开号：US7915255B2

  公开（公告）日：2011-03-29
• US7943593B2
  申请人：——

  公开号：US7943593B2

  公开（公告）日：2011-05-17
• US8268873B2
  申请人：——

  公开号：US8268873B2

  公开（公告）日：2012-09-18