2-Fluoro-N-pentyl-acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Fluoro-N-pentyl-acetamide
• 英文别名: 2-fluoro-N-pentylacetamide
• 化学式: C₇H₁₄FNO
• 分子量: 147.193
• InChiKey: JQMSLBHIYRQHTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  氟代乙酰氯 、 1-氨基戊烷 在 氢氧化钾 作用下， 以 乙醚 为溶剂， 反应 5.0h， 以55%的产率得到2-Fluoro-N-pentyl-acetamide
  参考文献：
  名称：

  Synthesis of some new N-monosubstituted fluoroacetamides

  摘要：

  Twenty new N-monosubstituted fluoroacetamides with potential toxicological proper-ties have been synthesized by acylation of the corresponding amines with fluoroacetyl chloride. The substituents were cycloalkyl or various alkyl (with straight or branched carbon chain) groups. The yields ranged from 50 to 92%.

  DOI：

  10.1016/s0022-1139(00)82416-1

文献信息

• Methods for Measuring Consumption of Amino Acid N-Carboxyanhydrides during Manufacture of Glatiramer Acetate
  申请人：Momenta Pharmaceuticals, Inc.

  公开号：US20220025115A1

  公开（公告）日：2022-01-27

  Methods for assessing and/or selecting as suitable for commercial release glatiramer acetate, including assessing the consumption, and/or relative reaction kinetics of one or more the amino acid N-Carboxyanhydrides (NCAs) present during the first step of the polymerization reaction in the glatiramer acetate manufacturing process are provided.

  提供了评估和/或选择适合商业发布的醋酸格拉替麦（glatiramer acetate）的方法，包括评估在醋酸格拉替麦制造过程的第一步中存在的一个或多个氨基酸N-羧基酸酐（NCAs）的消耗和/或相对反应动力学。
• Synthesis of some new N-monosubstituted fluoroacetamides
  作者：S. Mis̆c̆ević、D. Minić、S. Petrović

  DOI：10.1016/s0022-1139(00)82416-1

  日期：1992.11

  Twenty new N-monosubstituted fluoroacetamides with potential toxicological proper-ties have been synthesized by acylation of the corresponding amines with fluoroacetyl chloride. The substituents were cycloalkyl or various alkyl (with straight or branched carbon chain) groups. The yields ranged from 50 to 92%.